Search results for "Recovery"
Article
Automated harvesting and 2-step purification of unclarified mammalian cell-culture broths containing antibodies
The mean recovery of purified material from the culture-broth was 66.7%, representing a 20% increase compared to that of the manual process. Moreover, the automated process reduced by 3-fold the amoun…
Article
Risk Assessment and Mitigation in Biopharmaceutical Manufacturing
It is then a matter of developing recovery plans in the event of a disruption.
References
1. ICH, Q9 Quality Risk Management (ICH, June 2006).
2. ICH, Q10 Pharmaceutical Quality System (IC…
Article
Re-use of Protein A Resin: Fouling and Economics
It has been shown that the extended use of a resin results in decrease in its binding capacity, a decrease in product recovery, and a loss of Protein A ligands (9). Recent innovations in Protein A-aff…
Article
Challenges of Protein Aggregation During Purification
Changing the surface chemistry
Downstream processing for recovery and purification is achieved in several steps by exploiting the differences in the affinities, charges, sizes, hydrophobicities, a…
Article
Q&As with Industry Leaders
…partment of Biotechnology, BOKU
Recovery of Biological Products Conference Series
Günter Jagschies, Cyt…
Article
Trends in Downstream Bioprocessing
Downstream processing involves the recovery and purification of protein therapeutics for biopharmaceuticals, vaccines, and other biologics. It involves the removal of insoluble cell debris and parti…
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
Samples containing antibodies in cell culture fluid were injected onto a Protein A column for antibody recovery, then the purified antibody sample was automatically injected onto the size exclusion co…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The aim of this white paper is to demonstrate how Cytiva single-use products can be applied in the field of vaccine manufacturing. The white paper includes a brief discussion around modern vacci…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
Newer classes of biotherapies will require innovations in processing technology.
By Glen R. Bolton, Bernard N. Violand, Richard S. Wright, Shujun Sun, Khurram M. Sunasara, Kathleen Watson, Johna…