Search results for "Recovery" in Articles / App Notes
Article
Updating Viral Clearance for New Biologic Modalities
Viral clearance processes and guidance must evolve along with newer biotherapeutic modalities.
By Feliza Mirasol
Ensuring viral clearance (i.e., removal) in downstream purification has becom…
Article
Eliminating Residual Impurities Starts with a Strategic Plan
If derivatization is necessary to improve the sensitivity and detectability of the analyte in question, any loss in recovery must be accounted for. Filtration of samples must not cause any interferenc…
Article
Flexible Facilities for Viral Vector Manufacturing
Single-use and modular systems will meet demand for rapid implementation at different scales.
By Jennifer Markarian
Industry experts have noted that there are limitations in the…
Article
The Evolving Role of Starting Materials in Cell and Gene Therapy
Post-thaw recovery of MSCs in culture for a 24-hour period allows these cells to fully regain their functional potency (10).
Cell therapy source material losses resulting from sub-optimal cell p…
Article
Addressing the Complex Nature of Downstream Processing with QbD
Pressure excursions, including what may happen during product recovery buffer flushes, have sometimes been shown to lead to viral break-through during validation studies. We have adopted a risk mitiga…
Article
Nurturing Knowledge from Disparate Data Streams
“It may be argued, for example, that the relatively simple process of recovering and reviewing chart recordings from a well-maintained paper archive has advantages over the recovery of data from older…
Article
Supply Chain Challenges for Single-Use Systems
…g/forecasting, capacity planning, business continuity planning, change control management, disaster recovery planning, supply-chain mapping, and continuous improvement. At MilliporeSigma, a cross-fun…
Article
Challenges in Cell Harvesting Prompt Enhancements
al, “Recovery and Purification Process Development for Monoclonal Antibody Production,” MAbs online, DOI: 10.4161/mabs.2.5.12645, Sept. 1, 2010.
Article
Evaluation of Performance of a Disposable mAb Affinity Chromatography Column Used Over Multiple Process Cycles
Analysis of mAb purity and recovery as well as column bed integrity testing show that the column can be used with maintained performance for at least 50 cycles, providing significant process economic …
Article
Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
Equivalent mAb recovery and purity was achieved between the larger and the smaller scales, showing a robust and scalable process.
Click here to view the application note.