Search results for "Mab" in Articles / App Notes
Article
Continued Process Verification for Biopharma Manufacturing
Its recommendations are based on a typical cell culture production process for making a fictitious monoclonal antibody (mAb) product (3). Although this model plan does not provide examples of all aspe…
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
Feed-volume reduction can also reduce the cost of consumables, such as disposable bags and medium storage space. Because the feed dilutes the culture and reduces product concentration, the use of lowe…
Article
2014 Manufacturing Trends and Outlook
…of the respondents reported that their organizations manufacture therapeutic monoclonal antibodies (mAbs); more than 55% of those surveyed said they manufacture protein-based drugs other than mAbs. M…
Article
Optimizing KiH bispecific antibody chromatography steps
However, due to their increased complexity bsAbs often have higher levels of impurities in comparison to monoclonal antibodies (mAbs). This presents challenges to downstream processing.
This web a…
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Selected courses from cell culture and downstream process development to scale-up and manufacturing
…ine development
Bioreactor scaling
Filtration in bioprocessing
Purification of mAb variants
DoE in protein purification
Browse our catalog of free eLearning course…
Article
Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
…elution pH, resolution between hetero- and homodimers for bsAb’s, and removal of light chain from mAbs during elution when using MabSelect™ VL protein L resin. The video includes results of these exp…
Article
Video: The solution to smarter column packing
Packing modern chromatography resins at large scale requires a column capable of axial compression to ensure stable, reproducible packed beds. AxiChrom™ columns are low-pressure, axial compressi…
Article
A scalable single-use two-step plasmid purification process
While MAb processes have become much more efficient, production of mRNA and viral vectors is still hindered by the requirement for a reliable source of high-quality plasmid DNA (pDNA), which typically…
Article
Top challenges in recombinant protein purification process development
Well, for recombinant proteins, you often don't have an affinity solution, an affinity chromatography solution that can be used, which is very different from mAbs, which do have a great affinity solut…
Article
Chromatography processes for the diversified therapeutic antibody pipeline
Conventional chromatography protocols, used for many traditional mAbs may not be possible to use. Learn about how to adopt chromatography solutions for the diversified molecular pipeline.
Learn mor…