Search results for " concentration"
Article
Virus-like Particles as Therapeutic Moieties of the Future
NTA offers a non-invasive method to quickly analyze size distribution, identify aggregates, and calculate the concentration of particles (20). It is to be noted that enveloped, pleomorphic VLPs typica…
Article
Reimagining Affordable Biosimilars
Advances in preclinical development play a crucial role in reducing cost for developing biosimilars.
By Anurag S. Rathore, Narendra Chirmule, and Himanshu Malani
Drug development is …
Article
Mapping a Route for Cell and Gene Therapy Process Development
Precise in-process monitoring of complex parameters (metabolite concentrations, pH, oxygen and carbon dioxide, number and viability of the cells) within the bioreactor is necessary to gather the data …
Article
New Therapies Present Scaling Challenges
New Therapies Present Scaling Challenges
Manufacturing differences between traditional mAb therapies and newer biotherapeutics dictate whether processes should be scaled up, scaled out, or use an al…
Article
Optimizing Drug Safety and Efficacy of Complex Next-Generation Biologics
In recent years, the global biopharma industry has seen a rapidly advancing trend toward biotherapeutics or ‘biologic’ drugs—drugs that are produced from living organisms or contain components of li…
Article
Best Practices for Selecting a Top-Quality Cell Line
By counting the number of fluorescent droplets versus the total number of droplets, the concentration of the target DNA strand can be determined.
Custom probes can be used to select for cells c…
Article
Emerging Therapies Test Existing Bioanalytical Methods
Sampling from biodistribution studies should be performed at multiple time points and should include time of expected peak concentrations along with multiple late time points to determine both distrib…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption.
By Feliza Mirasol
ARTMOIS/STOCK.ADOBE.COM
Biopharmaceutical manufactu…
Article
The Outlook for CMO Outsourcing in 2019
By Eric Langer and Ronald A. Rader
Biopharmaceutical industry-related indicators and trends are supporting continued incremental increases in outsourcing of pre- and commercial AP…
Article
Achieving Process Balance with Perfusion Bioreactors
Advances in single-use technologies, sensors, and cell retention systems facilitate processes designed for the long run.
By Cynthia A. Challener
MG/Stock.Adobe.com
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