Search results for "bioprocessing" in Articles / App Notes
Article
Biopharma Says It Has an Evolution in New Technologies and Processes
Panelists suggested that a complete end-to-end continuous manufacturing process for bioprocessing may be an elusive goal; however, continuous operations may help in some segments of a full process.
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Reducing Cross-Contamination Risks in Process Chromatography
“With typical bioprocessing tools, a lot of effort and care goes into cleaning and cleaning validation of contact surfaces since any contamination in the purification process can be detrimental to the…
Article
Unifying Continuous Biomanufacturing Operations
Integrated continuous bioprocessing is already regularly being achieved in small research labs, according to Bonham-Carter, but has not yet made its mark in commercial, cGMP environments (8).
Pr…
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Single-use technologies in downstream process intensification
In bioprocessing, thorough cleaning is critical in order to take full benefit of the resin by removing impurities. When using conventional chromatography solutions, cleaning and cleaning validation …
Article
Fast Turnaround with Automated Column Packing
Traditionally, column packing has been an art rather than a science. The process can consume essential time and resources. Risking poor performance with a suboptimally packed bed is not an option. P…
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
…erived or microbial cell-derived? While these questions are most pertinent for the selection of the bioprocessing technologies required, they are also important for the design of the facility itself.…
Article
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
The authors describe the ways in which manufacturers can mitigate the risks related to the integrity of recombinant transgenes expressed in CHO cells.
By Luhong He, Christopher Frye
Abstract
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Article
Antibody Production in Microbial Hosts
Further, mAb production in microbial hosts such as bacterial cells completely abrogates the nuisance of glycosylation control and speeds up production timelines, further simplifying bioprocessing. The…
Article
Biopharma Outsourcing Activities Update
So essentially, this year BioPlan found something of a bimodal trend, more complex process outsourcing and greater outsourcing volume of basic bioprocessing, such as fill-finish, and other activities.…
Article
Evolution of the Monoclonal Antibody Purification Platform
The authors discuss the evolution of the purification platform for manufacturing of mAb therapeutics.
Monoclonal antibodies (mAb) increasingly form the majority share of the product pipeline…