Search results for " process"
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Interactive eBook - Understand and unlock the potential of digital scaling
Explore the possibilities with a digital process to reduce time and costs associated with your operations. Get started by downloading our free eBook.
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Good modeling practice: workflow and case study
Learn more about a recommended mechanistic modeling workflow for successful in silico chromatography process development. The workflow is illustrated with examples from a modeling case study a…
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Host cell protein quantitation using ELISA
Host cell proteins (HCPs) produced by cells during biologic manufacturing must be removed from the final product to protect patients. However, it’s challenging to detect HCP, and this step c…
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Get a strong start in oligonucleotide manufacturing
How can you harness their full potential? When starting process development, you need to know where to focus, and you need a scalable and flexible solution. Building on 40 years of experience, Cytiva …
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Antibody purification quiz
How well do you know antibodies and antibody purification?
Test your knowledge and gain insights in the purification of antibody variants – bsAbs, Fab, dAbs.
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Developing a HIC polishing step for removal of mAb aggregates
This article describes the development of a flow-through (FT) polishing step using hydrophobic interaction chromatography (HIC) to remove mAb aggregates.
It includes:
- The use of HTPD plate…
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How to Use Multiwell Plates With Manual Operation
FDA initiatives such as quality by design (QbD) put demands on better process understanding. High-throughput tools like PreDictor™ plates prefilled with chromatography resins make it possible to explo…
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Efficient chromatography buffer prep with inline dilution
We also compare the process economy of ILD versus manual buffer preparation — which is still the most common way to prepare buffers — by looking at the labor time, buffer volumes, floor space, and req…
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New hydrophobic interaction chromatography (HIC) handbook
Hydrophobic interaction chromatography (HIC) separates biomolecules under mild conditions according to differences in molecular hydrophobicity. HIC is often used as a next step to purify prote…
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Take part of the Southeast Asia BioChallenge
Looking to create the next breakthrough innovation? Cytiva is here to support you to bring your molecule to market in the shortest possible time. By applying to our BioChallenge, you stand …