Search results for " process" in Articles / App Notes
Article
Scaling Up an E. coli Upstream Process for Plasmid DNA Production — from 2.5 to 160 L scale Fermenters
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This article summarizes the results of Escherichia coli growth performance for plasmid production in a 5 L glass fermentor, which was scaled up to 80 and 160 L scale in Xcellerex™ X…
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Key Process Considerations for Therapeutic Oligonucleotides
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Learn more about scalable solutions for developing and manufacturing oligonucleotide therapeutics.
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Meeting the Process Development Challenges of a Diverse Biologic Pipeline
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Understanding the challenges novel and diverse biological molecules can create and how to manage these challenges is key to ensuring they reach patients safely and eff…
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Lentiviral Vector Upstream Process in Single-use Bioreactors
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Lentiviruses exhibit many desirable properties as gene transfer vehicles, such as high transduction efficiencies, ability to infect both dividing and nondivi…
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Process Development and Optimization Using the ReadyToProcess WAVE™ 25 Bioreactor System in Dual Mode
Download this application note to learn about the technical feasibility of the Method editor and operations in dual mode (where two parallel cultures are controlled independently) are demonstrated. …
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Developing an Efficient Adenovirus Downstream Purification Process
Adenovirus is one of the most frequently used viral vectors in the development of therapeutic vaccines and adenovirus is evaluated as vaccine delivery system in many preclinical and clinical studies…
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Automated In-Line Buffer Preparation from Ready-Made Stock Solutions in a mAb Process Step
Buffer preparation is both time-and space-consuming and can easily become a challenge in biomanufacturing. This application note describes a lean approach to buffer preparation by implementing in-li…
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Understanding Validation and Technical Transfer, Part 3
When correctly done, linking process to product to patient, validation ensures safe and effective drug and biologic products and benefits the patients whose health and wellbeing depend on them.
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Understanding Validation and Technical Transfer, Part I
Large-molecule drug products and attendant manufacturing processes often involve complex syntheses and purification steps that differ substantially from those employed for small-molecule pharmaceutica…
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Being Thorough When Transferring Technology
It’s a process that experts say requires time, organization, attention to detail, and communication (1). And developing a well-defined process is crucial: “A structured transfer process is critical to…