Search results for " process" in Posters
Poster
Improve operational efficiency in biomanufacturing with comprehensive automation solutions
However, equipment used are often connected only by process; that is, the bioprocess material passing between each of them. Often this connection is discontinuous, meaning equipment is controlled on a…
Poster
Adenovirus production in a single-use stirring tank bioreactor system
Anchorage-dependent cells cultured in roller bottles or cell factories are commonly used in these processes. However, scale-up using these techniques is complicated and limited by the surface availabl…
Poster
Reduce Risk of Failure in Your Virus Clearance Study by Choosing Robust Scale-Down Chromatography Tools
These studies are an essential part of process validation and are critical to ensure drug safety. Viral clearance studies are usually performed using a scale-down model mimicking the large-scale proce…
Poster
Opportunities, Challenges, and Economic Drivers for Start-to-Finish Continuous Biomanufacturing
Adopting advanced process design will need an accurate business case and risk profile for implementation. Within the risk profile, assurance of patient safety and supply through product quality demons…
Poster
Impact of sporicidal agent on MabSelect SuRe™ protein A resin lifetime
In this application note, the effects of treating MabSelect SuRe protein A affinity resin with 20 mM PAA every fourth process cycle for more than 100 cycles were investigated. The results show that t…
Poster
Modes of controlling charge variant distribution in Mab production
Charge variant distribution is a critical quality attribute for MAbs and is therefore of interest to monitor and control during the production process. In this study, we investigated the effects of ce…
Poster
Development of DoE based fed-batch strategies for high-producing CHO cell cultures
Typical standard platform processes rely on fixed-volume bolus feeding of concentrated supplements at regular intervals. However, such static approaches might result in over- or underfeeding. To mimic…
Poster
Development of a chemically defined medium for virus vaccine production in a duck suspension cell line
The primary goal of this project was to develop a chemically defined medium that could be used in a monophasic process while supporting the growth and production of a broad spectrum of different virus…
Poster
Effects of feeding strategy on CHO cell performance in fed-batch cultures
This work demonstrates the development of a fed-batch process for a Chinese hamster ovary (CHO) cell line producing a monoclonal antibody (mAb). The results emphasize the importance of an appropriate …
Poster
Purification of monoclonal antibodies using modern chromatography media and membranes
This white paper is a guide to the development of MAb purification platforms and provides an overview of Cytiva’s offering of process chromatography media (resins) and membranes for MAb purification…