Search results for " downstream"
Article
Downstream Processing Continues to Worry CMOs
Langer
Downstream processing continues to be a significant pain point for contract manufacturing organizations (CMOs), and downstream-fueled bottlenecks don’t appear to show any signs of abating, …
Article
Trends in Downstream Bioprocessing
…nology Industry Council confirmed that a leading 24% of bioprocessing decision-makers indicated that downstream processing would be the biggest trend in 2013 (1).
Although much of the discussion …
Article
QbD and PAT in Upstream and Downstream Processing
McKnight (Genentech): CQAs are defined for the product, not identified as part of upstream or downstream portions of the manufacturing process. There are key performance indicators (KPIs) that are def…
Article
Addressing the Complex Nature of Downstream Processing with QbD
Challenges of QbD in downstream processing
With the complex nature of biologics comes more complex quality concerns. Joey Studts, director late-stage downstream development in the bioprocessing d…
Article
Using Single-Use Technologies in Downstream Processing
While the industry has used SUS in upstream processing for some time now, the use of single-use technologies is becoming popular in downstream processes as well. And it appears that the single-use tre…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
Increasing upstream titers and shrinking development timelines have posed several challenges to downstream process development of mAbs. Some of the major strategies and tools to address these challeng…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
However, downstream single-use systems are still evolving, as vendors work to improve performance in critical areas. This article summarizes some of the benefits and the challenges of employing single…
Article
Process Chromatography Selection for Downstream Processing Applications
Selecting the appropriate separation technology plays a big role in maximizing productivity in any downstream processing application. Some factors companies may consider when selecting a separation te…
Article
Biopharma Moves to Integrated, Single-Use, Downstream Processing
A lack of single-use technologies
The greatest barrier for adoption of single-use technology for downstream applications has been a lack of adequate technology, particularly in the sensor area, th…
Article
Downstream Processing for Cell-Based Therapies
…ge-scale cell expansion; however, equally important is the development of large-scale harvesting and downstream processing operations. This paper presents and summarizes some of the challenges associ…