Search results for " downstream" in Articles / App Notes
Article
Announcing ÄKTA ready™ extended single-use system
ÄKTA ready™ extended system is a single-use liquid chromatography system designed for process scale-up and GMP manufacturing.
The system uses disposable flow paths and prepacked …
Article
How to Use Multiwell Plates With Manual Operation
During process development, aspects like robustness, scalability, and GMP production come into play. FDA initiatives such as quality by design (QbD) put demands on better process understan…
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Current Trends in Host Cell Protein Detection for Biologics Manufacturing
Commonly accepted HCP analytical methods, the challenges of HCP assay, and recommendations on what can easily be accomplished in-house and when it may be better to outsource.
Read more here…
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See a chromatography modeling software in action
Mechanistic models use computer simulations to decrease the number of experiments you need during process development.
The simulations are based on known physiochemical phenomena involved in ch…
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Top Process Development Trends for 2022 and a Look into 2023
Mainstream articles, no pun intended, covering tools and methodologies for smarter downstream process development were highly popular. Smart process development being a collection of approaches to imp…
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mRNA: The Messenger - mRNA Synthesis
… optimizing the mRNA template design, in vitro transcription, and process parameters to simplify the downstream processing.
EXPLORE THE mRNA UNIVERSE HERE >>
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Capture of Bispecific Antibodies and Removal of Product-Related Impurities
The similarities between these impurities present extra challenges for downstream processes, especially post-capture. One potential solution is to initiate polishing at the capture step using differen…
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Developing a Robust Bioprocess Using Mechanistic Models
The safety and efficacy of a biopharmaceutical drug are of the highest priority. Therefore, manufacturers have to design, implement and maintain measures to ensure that the bioprocess con…
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Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
…cosylation pattern, then folks are going to say, “I can't clean this up with chromatography in the downstream step. We have to go back to the beginning, get better control over the process.”
Ag…
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In silico Approaches towards Automated Biomanufacturing
The goal of manufacturing is to control and maintain a commercial process capable of consistently producing a drug of the highest quality and safety. As part of manufacturing science and t…