Search results for " titer" in Articles / App Notes
Article
Development of Purification for Challenging Fc-Fusion Proteins
In response, titers for monoclonal antibodies (mAbs) and Fc-fusion proteins have significantly increased (1-5).
Particularly for Fc-fusion proteins, these improvements have resulted in a …
Article
Technical and Process Economical Aspects of Using Capto™ Q and ReadyToProcess™Adsorber Q in mAb Polishing
For efficient operations, downstream purification needs to be able to handle high product titers at short process time. Compared with conventional chromatography, using stainless steel columns, the us…
Article
Improving Process-Scale Chromatography
…r changes in feed composition and improved ultraviolet capabilities to handle feed streams with high titers and/or backgrounds. The company has also recently introduced a new periodic counter-current…
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
The final yield here is determined by the product titer of the production bioreactor, combined with the efficiency of the downstream purification steps, both of which will be driven by the details of …
Article
Trends in Single-use Bioreactors
In addition, there are improved control systems that allow multiple unit operation and sophisticated feed strategies improving cell yield and increasing titer with single-use bioreactors. Ergonomic fe…
Article
Challenges and Trends in Biopharma Facility Design
In the case of producing a blockbuster drug, a large-scale stainless steel facility might actually be the most economical choice, especially if you have low titers and are starting from high-volume bi…
Article
Trends in Downstream Bioprocessing
By contrast, prior year comments included more detail and more indication of problems:
• Downstream still is not keeping up with increasing titers.
• Expression systems are producing 5 times w…
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
These 2D methods assessed both titer and size heterogeneity of the MAbs, demonstrating a streamlined workflow, and can be used for a variety of applications, including molecule assessment and clone se…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
Similar virus titers and HA concentrations were measured in the 10 L culture (data not shown) as in the 50 L culture (Fig 4).
A more detailed description of the cell culturing and virus infecti…
Article
A Closer Look at Affinity Ligands
Affinity ligands play an exciting role in the ever-growing sphere of downstream processing. In speaking with BioPharm International®, Phillip Elliott, PhD, associate director of Process Development,…