Search results for " titer" in Articles / App Notes

Article Flexible Facilities for Viral Vector Manufacturing
For example, for Duchene muscular dystrophy, the need (at current viral titers and downstream process recoveries) is about 200 L of production bioreactor culture per patient.” The batch size influence…

Article New Therapies Present Scaling Challenges
Unlike mAb production—where the goal is to produce higher titers of cells containing the antibody—in cell-therapy, the cell itself is the therapeutic agent. The cells must, therefore, keep their integ…

Article Cell-Culture Advances Test Bioreactor Performance Models
The evolution of cell-culture technology is driving the need for improvements in modeling solutions. By Cynthia A. Challener  Modeling and simulation are recognized to provide assistance i…

Article Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
All investigated bioreactor systems displayed similar trends over time and acceptable variability between cultures for viable cell density and viability profile, product titer, lactate, and product qu…

Article Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
While the multiple attributes method gains ground and traditional lab methods improve, broad efforts are underway to determine biopharmaceuticals’ most significant critical quality attributes and en…

Article What’s New in Upstream Technologies
The low-footprint integrated system delivers high cell densities and viral titers as well as homogeneous cell distribution throughout the fixed-bed. According to the company, the bioreactor offers…

Article A Look at the Affinity Chromatography Landscape
Resin suppliers have in recent years been challenged to increase the productivity of the capture chromatography process to enable more efficient purification of increasingly high titers. They have als…

Article Scaling Up Novel Therapies
Scaling Up Novel Therapies Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies? By Agnes S…

Article Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
The selected fed-batch culture conditions supported mAb titers of approximately 4 g/L in bioreactor cultures. 

Article The Challenge of Disruptive Technologies in Bioprocessing
“One issue that could occur is the load of a high titer product stream from a large-volume bioreactor onto a column with given, limited size and thus limited capacity (similar with filters), and all o…

Show All Results

Previous PageNext Page