Search results for " titer" in Articles / App Notes
Article
Continuous Manufacturing: A Changing Processing Paradigm
These procedures repeat in subsequent columns, helping to balance downstream productivity with upstream titers. Several equipment manufacturers, such as Novasep, Tarpon Biosystems, Cytiva, Semba, and …
Article
Viral Clearance Challenges in Bioprocessing
“Access to high titer virus preparations in testing labs is one way to achieve high clearance levels, and if complete clearance is observed across the unit operations, high log reduction values (LRVs)…
Article
Challenges of Protein Aggregation During Purification
While most aggregates are formed during upstream operations, and the risk for aggregate formation at the cellular level has increased as titers have increased, if unsuitable conditions are selected fo…
Article
Pharma Investments Reflect Key Industry Trends
First is the shift to biologic-based drugs, which has occurred along with a dramatic increase in the productivity, mainly in terms of much higher titers, of biopharmaceutical processes. “While demand …
Article
A Q&A With Parrish Galliher About Adopting Single-Use Systems
There are other factors that are helping to mitigate the risk as well—smaller markets, increased titers and improved processes help shrink plant-sizes ten-fold. And, since single-use facilities are sm…
Article
Q&As with Industry Leaders
… Cytiva
Cell Culture Media Considerations and Optimization for Improved Titers and Protein Quality
Peggy Lio, Senior Director of Global Cell Culture Servic…
Article
Raw Material Variability
Common examples would be out of specification for a product critical quality attribute (CQA), slower cell growth, low titer, and evidence of extraneous matter following visual inspection.
Fixing…
Article
Predicting Progress in Protein Aggregation
“Cells may stop secreting a protein if it takes on a new, aggregated form, leading to low titers and reduced yields and productivity. In addition, the formation of larger precipitates can cause the ph…
Article
Best Practices in Adopting Single-Use Systems
Moreover, the 5- to 10-fold improvement in product titers for monoclonal antibodies over the past 15 years has nearly eliminated arguments against single-use based on scale. Bioprocessors can now gene…
Article
QbD and PAT in Upstream and Downstream Processing
To gain perspective on the implementation of quality by design (QbD) and process analytical technology (PAT) in biopharmaceutical processing, BioPharm International spoke with Clinton Weber, as…