Search results for " titer" in Articles / App Notes

Article Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Essential Pharmaceuticals provides an animal-component free media that boosts titer and enhances protein quality. It can be difficult to change or improve processes with the strict regulations around …

Article Process Chromatography Selection for Downstream Processing Applications
Improvements in upstream processing have increased titers, shifting bottlenecks downstream from being a volumetric issue to where it is mainly the binding capacity of the resin that is limiting. T…

Article Perfusion in the 21st Century
Dramatic increases in the titers achievable with fed-batch culture, which reached levels as high as 4.7g/L (3), eventually eliminated the need to pursue continuous processing for increased productivit…

Article Downstream Processing Continues to Worry CMOs
Downstream continues to fail to keep up with the recent advances in upstream yield and titers. Reference 1. BioPlan Associates, 13th Annual Report and Survey of Biopharmaceutical Manufacturi…

Article Tools for Continuous Bioprocessing Development
These online measurements are supplemented by sample removal for offine measurements of glucose, viability, titer, and product quality (13). The device can use up to 324 cultures simultaneously, allow…

Article Biopharma in 2015: A Year for Approvals and Innovations
…namic Control in Periodic Counter-Current Chromatography Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies Trends in Single-use Bioreactors Process economy and product…

Article Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
Figure 2: Characterization of titer at harvest for a model two-dimensional process space spanning a range of dissolved oxygen tension (DOT) and pH values. By using DoE, it is po…

Article Implications of Cell Culture Conditions on Protein Glycosylation
Therefore, rather then only selecting for clones with the highest titer, as is usually the case for innovator drugs, selection is first for biosimilarity, which may mean that some of the highest produ…

Article Fluid Handling in Biopharma Facilities
Peuker (Sartorius Stedim Biotech): The customer should be aware of the process he will realize: process volume, process titer, future processes, etc. We made the best experiences with process simulati…

Article Continuous Chromatography: Trends, Definitions and Approaches
For the very low titer processes, or rather for the cases where the ratio of capacity-to-feed concentration is very high, even a 2-column system will be sufficient. Can you comment on the import…

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