Search results for "scale-up" in Articles / App Notes
Article
Digitalization: The Route to Biopharma 4.0
Scientific knowledge comprises process development and validation, whereas technical know-how involves process definition and scale-up for commercial production. Multiple organizations need to collabo…
Article
Using Digital Twins to Model Process Chromatography
…s, considering the small operating window at manufacturing scale and prohibitive expense of testing scale-up conditions. Models are typically calibrated using lab-scale data for material and cost eff…
Article
Cell-free Expression Systems Pose Cell Culture Alternative
But for clinical, the scale-up production is still under development. As early as 2011, J.F. Zawada et al. have successfully scaled up Escherichia coli (E. coli) cell-free expression of cytokines to 1…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
…vides a rapid solution for industrialization, frequently limiting process development risks, robust scale-up strategies, and the ability to produce industrial quantities using single-use technologies…
Article
Cell-Culture Advances Test Bioreactor Performance Models
Traditional, reliable method
Typically, bench-top bioreactors are operated in the performance design space of larger bioreactors to model scale-up performance, according to Parrish M. Galliher, …
Article
Moving PAT from Concept to Reality
Furthermore, asserts Grieb, a well-characterized and monitored process together with scalable hardware can significantly reduce the cost and efforts of process scale-up and scale-down. Overall, theref…
Article
Development of column packing methods based on pressure flow measurements
…s, and the optimization of a suitable degree of bed compression when developing packing methods for scale-up.
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Article
Modeling Bioreactor Performance
Modeling is used to gain insight into not only bioreactor performance, but to evaluate the economics and operational excellence of bioprocesses, as well as for process optimization (scale-up, scale-do…
Article
A Q&A on Bioprocessing Trends and Technologies at INTERPHEX 2016
The agency has accelerated approvals of breakthrough drugs, but identified the need for earlier scale-up chemistry, manufacturing, and controls (CMC) work. Equipment manufacturers displayed systems th…
Article
Biopharma Manufacturers Respond to Ebola Crisis
Tekmira’s antiviral utilizing lipid nanoparticle technology has been authorized for emergency use and is considering options for scale-up to produce some 900 doses by early 2015. And Sarepta Therapeut…