Search results for " Protein A" in Articles / App Notes
Article
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
Spivey and Lane
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Analytic considerations for upstream processing – covering Process Analytic Technology (PAT), time-savings versus off-line ana…
Article
Tips for Purifying and Analyzing Cryo-EM Samples
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Cryogenic electron microscopy (cryo-EM) provides possibilities to determine structures for more challenging proteins, such as membrane proteins and larger protein compl…
Article
Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
Studies and rankings showed that aggregation and Protein A fragmentation were crucial CQAs, Adkins said. Upstream, the most important CQAs include glucose concentration and cell mobility; downstream, …
Article
Preclinical Evaluation of Product Related Impurities and Variants
For example, the cystine/DTT ratio is governed by the number of cysteine residues in the protein and thus the number of disulfide bonds necessary for the protein to assume its functional native confor…
Article
ADC Development Robust Despite Lackluster Performance
Instead, the company’s approach is to use the protein as a cancer-associated-fibroblast-specific vehicle to internalize cytotoxic molecules because MTX5 is naturally capable of internalizing molecules…
Article
From Darwin to Recombinant Fc Multimers
Topics from a Darwinistic viewpoint on how business models are evolving in the Life Science industry to breakthrough research data from Momenta Pharmaceuticals on a recombinant trivalent Fc protein …
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Being Thorough When Transferring Technology
Communication and taking the time to develop the process are key to successful transfer and scale up of biologics.
By Susan Haigney
Editor's note: The following is an extended version of the…
Article
Affinity Chromatography Handbook in 3 Volumes
Affinity chromatography (AC) separates proteins on the basis of a reversible interaction between a protein (or group of proteins) and a specific ligand coupled to a chromatography matrix. The techni…
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Optimizing Resin Performance with Disposable Chromatography Solutions
Where we have seen significant advances in chromatography is with innovative new Protein A-derived media that are delivering improved capacity and stability, helping to increase production efficiency,…
Article
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