Search results for " screening" in Articles / App Notes
Article
Lessons Learned Accelerate Vaccine Development
“Quality by design, high-throughput screening, high-throughput sequencing, small-scale models to simulate large-scale production, artificial intelligence (both simulation and predictive models), and m…
Article
Developing Cleaning-in-Place Protocols
Cleaning conditions for chromatography media can be screened in a couple of working days using 96-well microtitre plate formats. A study with a Protein A resin illustrates the approach in this appli…
Article
Antibody Production in Microbial Hosts
Aglycosylated antibody fragments showing selective binding to FcγRIIa were isolated by yeast surface display and flow-cytometry screening. In another study, researchers employed a knob-into-hole techn…
Article
Robust Optimization, Simulation, and Effective Design Space
Main effects only and/or screening type experiments will not result in a robust solution.
Step Eight: Evaluate the set points using the design space
Once the set points have been selected, the vis…
Article
Biopharma Advances Demand Specialized Expertise
With this in mind, substitution of HPLC for UPLC, rapid microbiological screening methods, and investment in automated approaches to complex analytical problems such as protein sequencing are now bein…
Article
Optimization of Protein Expression in Escherichia Coli
May 01, 2015
By Siavash Bashiri, David Vikström, Nurzian Ismail
BioPharm International
Volume 28, Issue 5
Production of proteins for manufacturing therapeutics and pharmaceuticals is a c…
Article
Quality by Design and Extractable and Leachable Testing
Gross toxicity screening should also be confirmed for plastic and elastomeric components, such as that provided by USP Biological Evaluation Reactivity Tests, In Vivo (3), confirming the plastic meet…
Article
Viral Clearance Challenges in Bioprocessing
Equipment and process failures, such as inadequate raw material screening or failure of an upstream inactivation method, particularly those that go undetected, are also a concern with respect to poten…
Article
Analyzing Proteins Using SEC, MALS, and UHPLC
“While this issue is not difficult to overcome, generally a range of SEC columns is required for screening samples, and when working on the extremes of the column (total exclusion for very big protein…
Article
Challenges in Analytical Method Development and Validation
Experts give insight on method transfer, QbD, and regulations for analytical method development and validation for biopharmaceuticals.
The manufacture of biopharmaceuticals presents …