Search results for " scale-up"
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Industry Adoption of Single-Use Systems Remains Low
Under their agreement, Sartorius Stedim will equip Abzena’s San Diego process development lab with industry technologies that enable fast scale-up to 500 L initially and later to the 2000-L scale sing…
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Ultracentrifugation is, however, quite difficult to operate and scale-up. Other isolation approaches such as chromatography haven’t been as successful historically because of the surface heterogeneity…
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Process Development: What May Lie Ahead in 2018?
Single-Use in Full Force
Single-use technology continued to advance from scale-up and clinical applications to clinical manufacturing and the top-10 most popular articles on the Process Developmen…
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Transformative Medicines Challenge FDA and Manufacturers
And process scale-up further requires identification and qualification of thresholds and specifications.
Combos crucial
The process of developing and delivering cutting-edge gene therapies a…
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Development of Purification for Challenging Fc-Fusion Proteins
Development of Purification for Challenging Fc-Fusion Proteins
This study outlines methods for an alternative protein-polishing process for challenging proteins.
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Process Chromatography: Continuous Optimization
Ion exchange resins that offer high capacities at high linear flow rates help to scale-up processes for the economic production of large-volume mAb drugs, says Bulpin. “The base beads of these materia…
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Alternatively, upstream process scale-up can make use of perfusion reactors, which use a constant supply of cell-culture media while removing unwanted byproducts throughout a prolonged production run …
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Single-use Bioreactors Have Reached the Big Time
…cell therapy equipment and reagents to support next-generation technologies for new drugs, including scale-up models; regionalizing single-use manufacturing platforms for biologics (increasing local …
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Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…orum that continuous processing, ripe with innovation, will result in better quality products, fewer scale-up risks, and long-term economic advantages.
Last year also marked a significant step to…
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Improving Process-Scale Chromatography
By providing a single platform to connect data, technology transfer and scale-up from process development to final manufacturing scale are also simplified. “The benefits can be even greater when data …