Search results for " scale-up"
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Cell-Culture Advances Test Bioreactor Performance Models
Traditional, reliable method
Typically, bench-top bioreactors are operated in the performance design space of larger bioreactors to model scale-up performance, according to Parrish M. Galliher, …
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Moving PAT from Concept to Reality
Furthermore, asserts Grieb, a well-characterized and monitored process together with scalable hardware can significantly reduce the cost and efforts of process scale-up and scale-down. Overall, theref…
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Development of column packing methods based on pressure flow measurements
…ds, and the optimization of a suitable degree of bed compression when developing packing methods for scale-up.
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Modeling Bioreactor Performance
Doing so is particularly interesting for scale-up purposes in early development to understand how to scale certain scale-dependent parameters to large-scale production bioreactors, but also when movin…
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A Q&A on Bioprocessing Trends and Technologies at INTERPHEX 2016
The agency has accelerated approvals of breakthrough drugs, but identified the need for earlier scale-up chemistry, manufacturing, and controls (CMC) work. Equipment manufacturers displayed systems th…
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Biopharma Manufacturers Respond to Ebola Crisis
Tekmira’s antiviral utilizing lipid nanoparticle technology has been authorized for emergency use and is considering options for scale-up to produce some 900 doses by early 2015. And Sarepta Therapeut…
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PDA's Technical Report for Biotech Cleaning Validation
The performance of the cleaning process in the laboratory is then verified by conducting experiments in the pilot-plant or scale-up equipment. Adjustments to cleaning conditions may be made during the…
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Process development using a nonaffinity method vs Cytiva™ Protein Select™ resin
We also studied scale-up effects, and shared the results for runs performed onto a 10 cm bed height column.
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Explore ÄKTA pilot 600 in 3D
See how ÄKTA pilot™ 600 supports scale-up from process development to GMP clinical scale.
Explore this ÄKTA™ system in 3D
Article
Exosome isolation by tangential flow filtration and size exclusion chromatography
The workflows we describe are suitable for scale-up and combine tangential flow filtration (TFF) for the concentration of exosomes followed by gentle size exclusion chromatography (SEC) with our next-…