Search results for " titers" in Articles / App Notes
Article
Flexible Facilities for Viral Vector Manufacturing
For example, for Duchene muscular dystrophy, the need (at current viral titers and downstream process recoveries) is about 200 L of production bioreactor culture per patient.” The batch size influence…
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New Therapies Present Scaling Challenges
Unlike mAb production—where the goal is to produce higher titers of cells containing the antibody—in cell-therapy, the cell itself is the therapeutic agent. The cells must, therefore, keep their integ…
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Cell-Culture Advances Test Bioreactor Performance Models
The evolution of cell-culture technology is driving the need for improvements in modeling solutions.
By Cynthia A. Challener
Modeling and simulation are recognized to provide assistance i…
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Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
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In process development, it is desirable to test process parameters in small scale and later scale up the process into larger production scale. A theoretical scale-up study was per…
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Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
While the multiple attributes method gains ground and traditional lab methods improve, broad efforts are underway to determine biopharmaceuticals’ most significant critical quality attributes and en…
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What’s New in Upstream Technologies
The low-footprint integrated system delivers high cell densities and viral titers as well as homogeneous cell distribution throughout the fixed-bed.
According to the company, the bioreactor offers…
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A Look at the Affinity Chromatography Landscape
Resin suppliers have in recent years been challenged to increase the productivity of the capture chromatography process to enable more efficient purification of increasingly high titers. They have als…
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Scaling Up Novel Therapies
Scaling Up Novel Therapies
Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies?
By Agnes S…
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Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
The selected fed-batch culture conditions supported mAb titers of approximately 4 g/L in bioreactor cultures.
Article
The Challenge of Disruptive Technologies in Bioprocessing
The Challenge of Disruptive Technologies in BioprocessingIncreasing demand for biologics is driving the need for innovation in bioprocessing.
Jul 01, 2018
Increasing demand for biologics is drivin…