Search results for " titers" in Articles / App Notes
Article
Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
By Catherine Shaffer
Four biosimilars have been approved for the market by FDA as of February 2017, and more are in the pipeline. Now that biosimilars are here to stay, manufacturers are devel…
Article
Process Chromatography Selection for Downstream Processing Applications
Improvements in upstream processing have increased titers, shifting bottlenecks downstream from being a volumetric issue to where it is mainly the binding capacity of the resin that is limiting.
T…
Article
Perfusion in the 21st Century
Dramatic increases in the titers achievable with fed-batch culture, which reached levels as high as 4.7g/L (3), eventually eliminated the need to pursue continuous processing for increased productivit…
Article
Downstream Processing Continues to Worry CMOs
Downstream continues to fail to keep up with the recent advances in upstream yield and titers.
Reference
1. BioPlan Associates, 13th Annual Report and Survey of Biopharmaceutical Manufacturi…
Article
Tools for Continuous Bioprocessing Development
Could perfusion microbioreactors bring more agility to biomanufacturing?
By Rajeev J. Ram
In semiconductor manufacturing, for example, a thorough understanding of process variation allows co…
Article
Biopharma in 2015: A Year for Approvals and Innovations
…namic Control in Periodic Counter-Current Chromatography
Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies
Trends in Single-use Bioreactors
Process economy and product…
Article
Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
Use of a subspace model is a viable method to characterize process space variables and optimize process performance.
By Colin Jaques, Daniela Lega
Over the past decade, two improved capabili…
Article
Implications of Cell Culture Conditions on Protein Glycosylation
The authors present a review of the techniques commonly used for glycosylation analysis.
By Michiel E. Ultee, PhD, Dr. Richard Easton
This article reviews the implications of cell-culture co…
Article
Fluid Handling in Biopharma Facilities
Industry experts discuss challenges, trends, and innovations in fluid handling.
By Susan Haigney
Contamination prevention in biopharmaceutical manufacturing is crucial, and the proper handling…
Article
Continuous Chromatography: Trends, Definitions and Approaches
Process Development Forum speaks with Karol Lacki, Customer Collaborations Leader at Cytiva, about continuous chromatography.
There is a lot of attention being paid to continuous chromat…