Search results for " Predictor"
Article
High-Throughput Process Development Handbook
The handbook describes how results obtained using PreDictor plates can be used to define process conditions for large-scale chromatography. Applications of PreDictor plates are provided, as well as pr…
Article
Miniaturization to Become Even More Successful
Several talks focused on the use of miniaturized columns and screening plates, such as PreDictor 96-well plates and PreDictor RoboColumn™ units, and the possibility of these formats to become even mor…
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Figure 2: Results of different binding conditions at different pH and NaCl concentrations are shown as an overlay of breakthrough curves generated on PreDictor RoboColumn units (Cytiva). The breakthro…
Article
Top Tips for Successful Development of Antibody Chromatography Processes
So for instance, PreDictor™ plates, plates, a 96-well format, where you can screen 96 different conditions in the same experiment. There are also small, miniature columns that can be utilized in the s…
Article
How to Use Multiwell Plates With Manual Operation
High-throughput tools like PreDictor™ plates prefilled with chromatography resins make it possible to explore a large characterized space for optimizing process conditions. They save time and require …
Article
Virus-like Particles as Therapeutic Moieties of the Future
An IVRP assay reports the qualitative and quantitative epitope composition of a VLP sample and is a good predictor of VLP potency. The results of the assay have been found to correlate well with human…
Poster
Comparison of Three Different Screening Techniques for Predicting Step Elution Conditions for a Cation Exchanger
Three different screening techniques using PreDictor™ plates are compared and discussed. Selected conditions were applied in column step elution experiments and antibody yield, pool volume and reducti…
Article
Scaling Up Novel Therapies
One example Ransohoff cites is plate-based chromatography resin screening, enabled by technologies such as Cytiva Predictor plates, that allow users to consider binding properties of resins and soluti…
Article
Developing Cleaning-in-Place Protocols
Cleaning conditions for chromatography media can be screened in a couple of working days using 96-well microtitre plate formats. A study with a Protein A resin illustrates the approach in this appli…
Article
Biopharma Advances Demand Specialized Expertise
Perhaps the greatest challenge is in clinical development of novel and originator molecules, where in-vitro model systems are still not a great predictor of clinical performance.
Rogers (SGS Life S…