Search results for " conjugates"
Article
Tackling Analytical Method Development for ADCs
Feb 01, 2015
By Cynthia Challener, PhD
BioPharm International
Volume 28, Issue 2
The targeted therapy possible with antibody-drug conjugates (ADCs) makes them an attractive class of …
Article
ADC Development Robust Despite Lackluster Performance
Zulueta, “Antibody Drug Conjugates Against Tumor Stroma: The Beginning of the End? [2],” accessed Oct. 23, 2017.
2. Pfizer, “Pfizer Receives FDA Approval for Mylotarg (gemtuzumab ozogamicin) [3]…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
…ials (17–21) including antibody fragments, single-domain mAbs, Fc-fusions, vaccines, antibody-drug conjugates, nonantibody protein scaffolds, PEGylated proteins and peptides, and viral vectors.
…
Article
Single-Domain Antibodies for Brain Targeting
…ariants (diabodies, triabodies, minibodies, sdAbs) along with antibody-drug or antibody-nanoparticle conjugates are emerging as credible alternatives. Many of these products are under clinical invest…
Article
Witnessing Major Growth in Next-Generation Antibodies
The global market for next-generation antibodies, including antibody drug conjugates (ADCs), engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar ant…
Article
Evolving demands of process development services
And, more recently, there has been a high demand for the CDMOs that can handle oligos, peptides, and various complex conjugates. Novel conjugates involving combinations of oligos, peptides, high poten…
Article
Extractables Studies for Single Use Systems Used in ADC Manufacturing, Part 1
Single‑use (SU) systems have great potential in antibody‑drug conjugates (ADC) manufacturing. The use of organic solvents in the ADC process might , however, raise questions about potential leac…
Article
Being Thorough When Transferring Technology
BioPharm: Are there specific challenges for the tech transfer of antibody-drug conjugates (ADCs)? Monoclonal antibodies? Cell therapies?
Moscariello and Young (CMC Biologics): The major challenges…
Article
SEC in the Modern Downstream Purification Process
The separations of antibody-drug conjugates from the unbound payload molecule are also amenable to SEC. In these types of applications, the payload molecule (usually a cytotoxin) is added in a signifi…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
In a pandemic, genetic vaccines offer several advantages over traditional approaches.
By Cynthia A. Challener
For a vaccine to be effective, the components of the disease o…