Search results for " multimodal"
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Fundamentals of Mixed Mode (Multimodal) Chromatography
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Top Tips for Successful Development of Antibody Chromatography Processes
If we change this to a multimodal anion exchange step, instead, you have a much better probability of removing aggregates. The hydrophobicity that the multimodal ligands introduces are a lot more effi…
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Improving Process-Scale Chromatography
Alternatives to Protein A chromatography are available based on techniques such as precipitation, ion exchangers, and multimodals/mimetics. “It is challenging to compete on selectivity with the years …
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A Q&A With Prof. Alois Jungbauer: The Role of HIC in Biotech
Maybe it was not as advantageous as first indicated?
At the conference there were presentations on multimodal chromatography. How do you value multimodal chromatography compared to HIC?
Multim…
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Process Chromatography: Continuous Optimization
The past decade has, in fact, seen a steady increase in usage of multimodal chromatography resins, according to Westman. Because these resins separate molecules based on more than one mode of action, …
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Evolution of the Monoclonal Antibody Purification Platform
Use of multimodal chromatography
Recently, mixed-mode, ion-exchange ligands with enhanced binding strength for aggregates through the addition of hydrophobic functionality have been brought to mar…
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HTPD: Optimizing a mAb Chromatography Polishing Step
In this webinar, a case study using high throughput process development tools, optimizing process conditions for a mAb polishing step using a multimodal chromatography resin (Capto MMC ImpRes), will b…
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Process Chromatography Selection for Downstream Processing Applications
For these molecules, chromatographic techniques such as ion-exchange, hydrophobic interaction chromatography, and multimodal resins are common. Affinity resins like Capto L (antigen-binding fragments …
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High-Throughput Process Development in an Historical Environment
As an example, John Welsh from Merck presented a collaboration with Cytiva on the development of the next- generation multimodal chromatography resins and how high throughput techniques and different …
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Chromatography for the Diversified Antibody Pipeline
We have multimodal resin which is good at aggregate removal which targets product related impurities. The HIC resins also demonstrated as good aggregate removers—we have the usual suspects such as agg…