Search results for " pcc"
Poster
Scalable Continuous Chromatography Process for Enhanced Efficiency in Biomanufacturing
In this poster presented at the Recovery XVIII conference, based on data from a collaboration between Merck and Cytiva, we use two case studies to demonstrate that PCC is a robust and scalable technol…
Article
Continuous Processing for the Production of Biopharmaceuticals
The PCC system was directly integrated into this and ran continuously for 30 days. Product quality was found to be comparable with batch-column operation. The advantage of this assembly was realized i…
Article
Maximize resin usage with continuous bioprocessing
In a PCC setup, columns are switched between the loading and nonloading steps, such as wash and elution. PCC increases the use of available resin and enables smaller equipment footprint and shorter pr…
Article
Continuous Chromatography: Trends, Definitions and Approaches
There is a lot of attention being paid to continuous chromatography, and several different terms are being used: SMB, PCC, MCC. What is your view on the terminology? Is there a difference among them? …
Article
Making the Move to Continuous Chromatography
Making the Move to Continuous Chromatography
Early adopters are benefiting from lower costs and increased productivity.
By Cynthia A. Challener
Tashatuvango/Shu…
Poster
Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was…
Poster
Integration of continuous upstream and downstream operations in mAb production
Process intensification is gaining interest as a strategy to reduce production costs, while improving product quality and throughput in the manufacturing of biopharmaceuticals. For a competitive pro…
Poster
Continuous chromatography in downstream processing of a monoclonal antibody
In this study, periodic counter current (PCC) chromatography and straight-through processing (STP) technologies were evaluated in a continuous three-step monclonal antibody (MAb) purification proces…
Article
Technology Innovations Improve Process Chromatography Performance
As technology matures, inefficiencies and process limitations in downstream process chromatography are improved.
By Feliza Mirasol
Selecting an appropriate separation technology fo…
Article
Integrated Semi-Continuous Process for mAb Production
A complete process for the production of a biopharmaceutical consists of a great number of distinct unit operations, for example, cell culture, filtration, and chromatography. Linking these differen…