Search results for " production" in Articles / App Notes
Article
Cell-Culture Advances Test Bioreactor Performance Models
The evolution of cell-culture technology is driving the need for improvements in modeling solutions.
By Cynthia A. Challener
Modeling and simulation are recognized to provide assistance i…
Article
Challenges in Cell Harvesting Prompt Enhancements
al, “Recovery and Purification Process Development for Monoclonal Antibody Production,” MAbs online, DOI: 10.4161/mabs.2.5.12645, Sept. 1, 2010.
Article
Biopharma Says It Has an Evolution in New Technologies and Processes
Cytiva introduced prefabricated, modular KUBio manufacturing units for the production of viral vector-based therapeutics including viral-vector based vaccines, oncolytic viruses, and gene and cell the…
Article
Fusion Proteins Pose Manufacturability Challenges
Some fusion proteins are also prone to proteolytic degradation during production and/or after therapeutic administration, according to Carter. This issue can sometimes be overcome by modifying the jun…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
This specificity is of particular relevance to the production of biotech therapeutics, which require high standards of purity. However, development and optimization of a process chromatography step pr…
Article
Ensuring the Biological Integrity of Raw Materials
The contamination traced back to the use of raw materials originating from animals in the production of the vaccine, and highlighted the need for better procedures to eliminate viral contamination and…
Article
Automating Processes in Upstream Processing
By Susan Haigney
BioPharm International spoke with Trevor Marshall, director of enterprise systems integration at Zenith Technologies, about automating processes in upstream processing.
BioP…
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
84, each media needs to be specifically identified from other media during release testing prior to use in production (1, 2).
Cell-culture media contain multiple components such as hormones, vitam…
Article
Going Small to Achieve Success on the Commercial Scale
For example, it is important to use the same feed used for production runs in scale-down modeling runs; therefore, modeling runs must be scheduled when the feed is available. In many cases, that isn’t…
Article
Robust Optimization, Simulation, and Effective Design Space
Jul 01, 2015
By Thomas A. Little, PhD
BioPharm International
Volume 28, Issue 7, pg 40–44
Approaches to the generation of process models, optimization techniques, and application of …