Search results for " production" in Articles / App Notes
Article
Cytiva Opens Biotechnology Manufacturing Center in UK
GE Healthcare Opens Biotechnology Manufacturing Center in UK
Cytiva is opening a biotechnology manufacturing center at the Stevenage Bioscience Catalyst (SBC) Open Innovation Campus, in Stevenage…
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
First, recombinant production of all enzymes was achieved in Escherichia coli or yeast hosts. This required discovery of some genes encoding plant enzymes that had never been produced recombinantly (e…
Article
Real Time Continuous Microbiological Monitoring
NAD+/NADH drives adenosine triphosphate production in the cytosol by glycolysis and in the mitochondria by oxidative phosphorylation. The presence of NADH in the cell is a good indication of active me…
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Overcoming Buffer Challenges With In-Line Conditioning
Formulating buffers from single-component stock solutions eliminates the need of conductivity and pH post-adjustments and adds the flexibility of on-demand production of different buffer formulations …
Article
Analysis of Glycosylation in Biosimilars
A step-wise process is used to characterize glycans and understand the functioning of a molecule for biosimilar development.
The structures of protein drugs such as monoclonal antibodies are mad…
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Fed-batch supplements to boost cell culture performance
This application note demonstrates the enhanced performance of commonly used cell lines for MAb production when supplemented with HyClone™ cell culture supplements. Cultures of Chinese hamster ovary (…
Article
Optimization of Protein Expression in Escherichia Coli
This increases the cost of production. In addition, only a fraction of the isolated protein will refold to give active protein, resulting in loss of yield.
The addition of such fusion partners as m…
Article
USP Publishes Monoclonal Antibody Guidelines
Mar 02, 2015
By Dale Schmidt, M.S., Anita Y. Szajek, PhD, Fouad Atouf, PhD, Tina S. Morris, PhD
BioPharm International
Volume 3, Issue 28
As FDA gears up towards approving biosimilar dru…
Article
Analyzing Proteins Using SEC, MALS, and UHPLC
Thus, even at low levels, their presence can lead to antibody production against the drug, resulting in more rapid clearance and lower efficacy, and at higher levels, anaphylaxis,” he explains.
In…
Article
Q&A with Eric Langer, about the evolution of the role of CMO’s in Bioprocessing
This week Process Development Forum speaks with Eric Langer, President and Managing Partner at BioPlan Associates, and the author of a number of biopharma studies, about the role of CMO’s in Bioproc…