Search results for " antibody" in Articles / App Notes
Article
From Darwin to Recombinant Fc Multimers
Matthias Germer from Biotest Germany presented a novel polyclonal antibody preparation containing IgM (23%), IgA (21%), and IgG (56%) for the treatment of severe community-acquired pneumonia (sCAP), w…
Article
Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
In the following section, a case study of of a monoclonal antibody (mAb) in an IEC model is presented.
Mechanistic modeling for development of an ion-exchange chromatography step to purify m…
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HTPD: Optimizing a mAb Chromatography Polishing Step
Development of robust purification processes requires significant time and resources. In addition, steadily increasing demands from regulatory authorities for better understanding and control of man…
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Efficient concentration of a low-titer bovine IgG with high recovery in low volume
The described process enabled concentration of a bovine IgG antibody from 50.0 to 0.165 L in less than 5 h.
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Reconciling Sensor Communication Gaps
The desirability of platform purification, best exemplified in monoclonal antibody (mAb) downstream processing, simultaneously creates and reduces the need for extensive downstream monitoring. Platfor…
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Biosimilars to Drive Modern Manufacturing Approaches
Reliable, high-quality products require innovative analytics and production.
By Jill Wechsler
As more biosimilars gain market approval in the United States, and manufacturers launch addition…
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A Second Modular Biopharma Facility Opens: KUBio in Hangzhou
To bring advanced biosimilar products to the Chinese market quickly, Pfizer’s Global Biotechnology Center will make use of Cytiva’s KUBio advanced modular manufacturing solution. KUBio modules …
Article
Affinity Chromatography Handbook in 3 Volumes
Affinity chromatography (AC) separates proteins on the basis of a reversible interaction between a protein (or group of proteins) and a specific ligand coupled to a chromatography matrix. The techni…
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Microbiological Testing: Time is of the Essence
Pressures to accelerate current and next-gen therapies are challenging traditional microbiological testing methods.
By Cynthia A. Challener
Effective microbiological testing during biopharmace…