Search results for "modeling" in Articles / App Notes
Article
Cytiva and GoSilico Agree to Co-market ChromX™ Mechanistic Modeling Software
The agreement facilitates the adoption of ChromX™ by scientists and users of resins, columns, and chromatography systems into their downstream process-development workflows to accelerate development…
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Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
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In process development, it is desirable to test process parameters in small scale and later scale up the process into larger production scale. A theoretical scale-up study was per…
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Going Small to Achieve Success on the Commercial Scale
He adds that timing and planning of modeling runs is also important and can negatively influence results if not done effectively. For example, it is important to use the same feed used for production …
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Digitalization: The Route to Biopharma 4.0
Recently, a hybrid modeling approach, combining both mechanistic modeling and data-driven modeling, has been shown to offer a multitude of benefits. For chromatography, relating data from sensor with …
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Determining Criticality, Part Two: DoE and Data-Driven Criticality
…h fermentors of 5000 to 25,000 L), hence, most biotech process development programs rely heavily on modeling the process at smaller or intermediate scale. Some process parameters may be independent o…
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Discovering the unknown: How does in silico process development change PD scientists’ work?
But what does it actually mean to perform process development in silico? Do I need to be a math expert? Where is modeling applicable? Will I not set foot in the lab ever again?
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Report from the 6th International HTPD Conference
A preconference day focused on getting up to speed with mechanistic modeling
This year, the week started with a pre-conference day about mechanistic chromatography modeling, organized by Cyt…
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Setting Up Bioprocessing Systems for Digital Transformation
“When the organization has confirmed that assets are working as expected, it can begin to implement more advanced modeling focused on the unit operation level. This layer focuses more on specific piec…
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Robust Optimization, Simulation, and Effective Design Space
Jul 01, 2015
By Thomas A. Little, PhD
BioPharm International
Volume 28, Issue 7, pg 40–44
Approaches to the generation of process models, optimization techniques, and application of …
Article
Putting Viral Clearance Capabilities to the Test
Process understanding and careful assessment of risks are essential in developing viral clearance programs.
By Rita C. Peters
nobeastsofierce/Shutterstock.com
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