Search results for "column" in Articles / App Notes
Article
Understanding Validation and Technical Transfer, Part 2
Qualification protocols are used for process equipment, such as tanks, mills, piping systems, autoclaves, ion exchange units, chromatography columns, and stopper washers. Validation protocols are used…
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Gain Efficiency in Process Development
The development of efficient manufacturing processes is a necessity for cost-effective production of biopharmaceuticals. By carefully designing and evaluating your experiments, sufficient informatio…
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Putting Viral Clearance Capabilities to the Test
“In addition, expanded ranges of critical operating parameters may be evaluated, and column cleaning and carry-over must be evaluated.”
In testing prior to Phase III, Gilljam notes, “Reduction of …
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Cleaning Protein A Resins with 1 M NaOH
The presence of cell culture nutrients in the harvest feed loaded on the capture column also exposes the protein A step to increased risk of microbial contamination. Historically, protein A resins hav…
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Single-Use Chromatography: Adapting to Manufacturing Scale
Single-use technologies offer the flexibility needed to meet the demands of multiproduct facilities. The capital investment is lower, and substantial time savings can be made when eliminating cleani…
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Full Single-Use Downstream Process? Not Any Time Soon.
Single-use technologies (SUTs) are here to stay. But where we see full single-use upstream processes, downstream is often a hybrid solution. Here’s why SUTs will not completely replace reuse systems…
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How Can A Chromatography Bead Free Up Your Time?
Have you ever considered how a resin bead in your chromatography column can affect your ion exchange (IEX) chromatography run time?
Read this blog and learn how you can optimize the time spen…
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Industry Adoption of Single-Use Systems Remains Low
Single-use technologies are starting to gain ground as capacity needs change, but industrywide adoption remains low.
By Feliza Mirasol
zli…
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Preclinical Evaluation of Product Related Impurities and Variants
The product understanding generated here can also be used when making decisions about pooling of process chromatography columns so as to achieve favorable process economics.
Conclusion
…
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Will My Buffers Work When Using an Inline Conditioning System?
The system can be used off-line as a standalone central buffer preparation station to feed different processes in the facility or in-line connected to a chromatography column using a built-in chromato…