Search results for " cell" in Articles / App Notes

Article Managing Residual Impurities During Downstream Processing
Challener Manufacture of protein and other biologic drug substances via cell culture or fermentation occurs with the natural, simultaneous production of other unwanted materials, particularly host-…

Article A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
…molality, quantitation of glucose, and folic acid, provides specific identity confirmation for seven cell-culture media with essentially similar composition that were examined in this study. The meth…

Article Best Practices in Qualification of Single-Use Systems
Single-use bioreactors are widely used in cell line expansion, and the use at production scale is increasing, notably in contract manufacturing. Single-use buffer filtration system and storage bag app…

Article Fermentation for the Future
Microbial expression is often preferred over cell culture for the production of smaller peptides and proteins that do not require glycosylation because the desired substances may be produced in much s…

Article Outsourcing Trends in Biopharmaceutical Manufacturing
The results over the past 10 years tell show that outsourcing is not only increasing across traditional systems including mammalian cell culture and microbial fermentations, but also across newer syst…

Article Comparing Protein A Resins for Monoclonal Antibody Purification
With greater economic pressure on monoclonal antibody (mAb) production for therapeutic and research uses, antibody titers in mammalian cell culture have increased dramatically over the past 20 years. …

Article Establishing a Robust Workflow to Identify GOCHO™ Clones
Our new cell line development platform uses the GOCHO™ host cell line to minimize the risk and timeline to develop high-performing clones suitable for manufacturing. LEARN MORE >>

Article Eliminating Residual Impurities Starts with a Strategic Plan
They can be derived from the host cell or the product itself, media components, surfactants, virus inactivation agents, inorganic or organic contaminants from permanent and single-use process equipmen…

Article Can Vaccine Development Be Safely Accelerated?
They possess a surface spike (S) glycoprotein that binds to host cell receptors, and the nature of this protein is believed to determine the main properties of each coronavirus. SARS-CoV was the first…

Article Case Study: Oncolytic Adenovirus Production
These viruses selectively replicate in tumor cells and effectively kill these cells without harming normal cells. Selectively engineered, the virus not only destructs the target tumor cell, but also s…

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