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Article Digital Technologies Aid Productivity and Growth
This can be especially useful in cell therapy manufacturing and distribution. Learn how digital technologies can aid productivity in cell therapy manufacturing and in bioprocessing  

Article Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Those technologies include more productive cell lines, single use, and powerful analytical methods. The problem of copying biologics Biologic drugs have revolutionized the pharmaceutical indus…

Article Modeling Bioreactor Performance
Challener Bioreactor design, including the geometry of the tank and impeller and the locations of inlets, has a direct impact on the performance of cell-culture and fermentation processes. Modelin…

Article Continuous Processing for the Production of Biopharmaceuticals
…opment of other separation technologies such as continuous chromatography, refolding, precipitation, cell lysis, filtration, and aqueous two-phase extraction (3). Table I presents a summary of recent…

Article Use of Multivariate Data Analysis in Bioprocessing
Among many others, some of the common applications of MVDA include analysis of data originating from spectroscopic measurements, analysis of data profiles from unit operations such as cell culture and…

Article Re-use of Protein A Resin: Fouling and Economics
Specificity of Protein A ligand towards mAb results in extremely effective clearance of host cell proteins (HCP), viruses, and DNA (2–5). The high selectivity is accompanied by reasonably good physioc…

Article Detecting Protein Aggregates and Evaluating their Immunogenicity
“These stages include formulation composition, presence of microbial or vial contaminants during cell culture, and storage,” notes Olcott. Work by Hasija et al. (2) on forced degradation studies in va…

Article Analyzing Proteins Using SEC, MALS, and UHPLC
While better connections between the tubing and shorter distances between cells can improve this situation, the best solution in this case is integration of all the detectors into a single unit. “Inte…

Article Q&As with Industry Leaders
…International Emma Lind, Product Manager, Chromatography Resins, Cytiva Optimizing your Cell Culture Process to Improve Productivity  Jeanne Linke Northrop, Biopharm International…

Article Trends in BioPharma Approvals in 2013
In terms of expression systems used, a total of eight of the products approved are expressed in mammalian cell lines (seven in CHO cells, one in Sp20), six are produced in yeast-based systems, four in…

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