Search results for " design" in Articles / App Notes
Article
A Q&A With Prof. Alois Jungbauer: The Role of HIC in Biotech
It is a good thing with the development of high throughput techniques and Design of Experiments. Otherwise, the multimodal chromatography approach would have been even more challenging. If we know the…
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Optimization of each phase in a chromatographic cycle has a positive impact on productivity.
By Anna Grönberg
An important area of focus for the biopharma industry is the elucidation and dev…
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USP Stresses Pharmacopeial Standards at CPhI China
The seminar was designed to explain the latest quality standards and regulatory updates to the more than 120 participants. Topics included global harmonization with industry standards and regulations,…
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A Bright Future for the Plasma Fractionation Industry
The advantages of this QbD approach were claimed to be better information for process design, clear justification of the process and product specifications, and well-structured process and product kno…
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Optimization of Protein Expression in Escherichia Coli
It is important to consider the entire process—from vector and insert design to bioreactor conditions—because each part of the process will have a huge impact on the final result.
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Article
Drug Discovery and Development in India
Government initiatives
According to Pachhapur, the government has taken many initiatives in accordance with India’s Department of Pharmaceuticals Pharma Vision 2020 (7), which is designed to make …
Article
Re-use of Protein A Resin: Fouling and Economics
These resins have been designed to keep pace with increasing bioreactor volumes and cell-culture expression levels and thereby prevent Protein A capture from becoming a bottleneck in the purification …
Article
Vaccine Development and Production Challenges Manufacturers
In addition, CDC was designing a phased-introduction study in Sierra Leone to compare the effect of early vs. later vaccination. The recent decline in new Ebola cases in Liberia, though, may necessita…
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Detecting Protein Aggregates and Evaluating their Immunogenicity
“Although components of the formulation are designed to preserve protein conformation, sometimes these excipients (e.g., human serum albumin, polysorbate) can interact with the protein and destabilize…
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SEC in the Modern Downstream Purification Process
Prior to a final polishing step, the intermediate puriï¬cation steps are designed to remove most of the process-related impurities, such as host-cell proteins, endotoxins, nucleic acids, and viruses…