Search results for " capacity"
Article
Contract Manufacturing Through the Years
The first was the shedding of excess capacity by global bio/pharmaceutical companies as older products went off patent and as the establishment of the European Union and North American Free Trade Agre…
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Process Chromatography Selection for Downstream Processing Applications
…ecipitation and flocculation techniques has recently proven to be an alternative for improved filter capacity in the clarification of high cell density cultures, as well as a means of reducing some p…
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Challenges and Trends in Biopharma Facility Design
The ability to produce more than one biomolecule, for example by incorporating single-use capacity, supports smaller-batch production of ‘niche’ medicines. Adapting legacy facilities to this more flex…
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The Development and Application of a Monoclonal Antibody Purification Platform
This increased the loading capacity of this step by a factor of up to 100. All other unit operations remained the same. The resulting process is shown in Figure 1 as process 3.
Then, the timeline …
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Automation Trend in Fill/Finish Reduces Contamination Risk
… according to BioPlan Associates’ 14th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production (2).
The advancement of automation, including robotics, is one area of p…
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Putting Viral Clearance Capabilities to the Test
“The study should be carefully designed to ensure the capacity to remove or inactivate virus is not over-estimated, applying ‘worst-case’ parameters to individual steps, where known.”
The key elem…
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Development of Purification for Challenging Fc-Fusion Proteins
Process capacity determination with column chromatography
The screening above with the desired purity was used as a starting condition for small-scale column experiments at a higher load …
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Continuous Manufacturing: A Changing Processing Paradigm
In batch chromatography, a resin is often not loaded at maximum capacity, and capture columns generally have to be cycled multiple times. A column in batch is typically loaded only approximately 80%, …
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Pharma Investments Reflect Key Industry Trends
AbbVie: AbbVie officially opened its newly expanded facility in Sligo, Ireland in June 2014 (announced in 2012), which provides manufacturing capacity to deliver on AbbVie’s existing portfolio of medi…
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Making the Move to Continuous Chromatography
Switching from batch to continuous allows for improved resin capacity utilization through continuous loading (overloading, in fact) of the column or membrane for increased process efficiency. It is pa…