Search results for " capacity" in Articles / App Notes
Article
The Development and Application of a Monoclonal Antibody Purification Platform
This increased the loading capacity of this step by a factor of up to 100. All other unit operations remained the same. The resulting process is shown in Figure 1 as process 3.
Then, the timeline …
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Automation Trend in Fill/Finish Reduces Contamination Risk
… according to BioPlan Associates’ 14th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production (2).
The advancement of automation, including robotics, is one area of p…
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Putting Viral Clearance Capabilities to the Test
“The study should be carefully designed to ensure the capacity to remove or inactivate virus is not over-estimated, applying ‘worst-case’ parameters to individual steps, where known.”
The key elem…
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Development of Purification for Challenging Fc-Fusion Proteins
Process capacity determination with column chromatography
The screening above with the desired purity was used as a starting condition for small-scale column experiments at a higher load …
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Continuous Manufacturing: A Changing Processing Paradigm
In batch chromatography, a resin is often not loaded at maximum capacity, and capture columns generally have to be cycled multiple times. A column in batch is typically loaded only approximately 80%, …
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Pharma Investments Reflect Key Industry Trends
AbbVie: AbbVie officially opened its newly expanded facility in Sligo, Ireland in June 2014 (announced in 2012), which provides manufacturing capacity to deliver on AbbVie’s existing portfolio of medi…
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Making the Move to Continuous Chromatography
Switching from batch to continuous allows for improved resin capacity utilization through continuous loading (overloading, in fact) of the column or membrane for increased process efficiency. It is pa…
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FDA Framework Spurs Advanced Therapies
Lonza anticipates that customers will require the ability to increase scale and capacity efficiently to keep pace with clinical development needs, which in some cases may conflict with the increased s…
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Technologies and Practices Must Evolve to Meet Demand
More than 45% of the respondents reported an increase in manufacturing capacity in 2014; 9.6% said their company increased outsourced manufacturing. Less than 2% reported a decrease in in-house manufa…
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Outsourcing Trends in Biopharmaceutical Manufacturing
According to BioPlan Associates’ 10th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production (1), outsourcing and off-shoring have migrated into much more high-value areas…