Search results for " capacity" in Articles / App Notes
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
At the same time, the production platform selected to manufacture clinical material must be scalable in order to enable the target capacity to be reached and promote cost-effectiveness. Adherent cell …
Article
Setting Up Bioprocessing Systems for Digital Transformation
Hahn points out that, for instance, pre-packed single-use chromatography columns of the same type may differ in terms of column packing and resin lot capacity. “In practical application, these differe…
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Innovative Chromatography Resins Can Improve Purity and Quality
…urther refined around key parameters, such as resolution, selectivity, pressure/flow properties, and capacity to ensure competitive downstream solutions into the future, Ihre says. “Such improvements…
Article
Technology Innovations Improve Process Chromatography Performance
“That dearth is seen especially through the limited dynamic binding capacity needed to process the high-titer cell culture harvest,” he says.
The performance reproducibility in column packing, whi…
Article
Best Practices for Selecting a Top-Quality Cell Line
The capacity of the cell line to cope with the secretory stresses associated with the high level of protein production, particularly with many of the newer, non-natural proteins such as bi-specifics o…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
Such was the viewpoint of one popular article, which explored some stumbling blocks to wider spread adoption of single-use systems in the biomanufacturing arena and how capacity needs are changing. …
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Process Economy Simulations on a Protein A Capture Step
This application note gives calculation examples that highlight scenarios where the enhanced capacity and alkaline‐stability of MabSelect PrismA can provide process economic benefits to large‐scal…
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FDA Seeks to Enhance Manufacturing of Cell and Gene Therapies
He acknowledged that the logistics of manufacturing autologous cells can be particularly challenging, and that limited capacity in cell lines stymie efforts to meet the demand for product development.…
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Challenges in Cell Harvesting Prompt Enhancements
This results in an added burden to filtration processes, however, which must have the capacity to handle the additive material as well as the mAb product (2).
Other challenges that innovations…
Article
Platform Technologies Improve Protein Expression
Ventria is in the process of doubling our production capacity with the platform to meet growing needs in developing new biotherapeutics, cell-culture media reagents for biomanufacturing, and industria…