Search results for " mixing" in Articles / App Notes
Article
The use of Xcellerex™ mixing system as slurry tank when packing chromatography columns
The capability of the mixing system to keep the chromatography medium (resin) in suspension and the possibility to integrate the system in column packing were studied. The results show that XDM Quad …
Article
Mixing dynamics in a large volume single use mixer
Large-volume mixers are mainly required in clinical three-scale and production-scale facilities where mixing efficiency is one of the key drivers of throughput efficiency. Upstream applications such …
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Using Xcellerex™ mixing system as a slurry tank when packing chromatography columns
The capability of the mixing system to keep the chromatography medium (resin) in suspension and the possibility to integrate the system in column packing were studied. Further, an evaluation of the ef…
Article
Fundamentals of Mixed Mode (Multimodal) Chromatography
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Article
Tools for Continuous Bioprocessing Development
A paper from ETH Zurich (funded by Novartis) demonstrated that geometric similarity fundamentally does not allow for scale invariance (from 3 L to 15,000 L) of kLa, shear stress, and mixing time simul…
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
This article will explore the traditional path from the laboratory to the clinic and how the fixed-bed technology provides an alternative solution to meet commercial demands.
By Alex Chatel and …
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Single-use Bioreactors Have Reached the Big Time
“When considering the workflow and objectives of running bioreactors, recent developments have focused on reducing complexity, improving mixing to achieve higher volumetric mass transfer coefficients …
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Modeling Bioreactor Performance
In general, process-specific data must also be generated to perform these modeling studies because oxygen transfer and mixing times differ depending on the medium used and the bioreactor fill volume a…
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Process Chromatography Selection for Downstream Processing Applications
Also, the ability to use concentrated buffer components and mixing them in-line under controlled conditions (in-line conditioning) has simplified the chromatographic operation. Other simplifications a…
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Cell-Culture Advances Test Bioreactor Performance Models
“Viscosity and solution property changes can fundamentally change mass-transfer mechanisms by impacting bubble size, bubble coalescence, mixing times, shear rates, and other parameters,” he explains. …