Search results for " inline"
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
…uid chromatography (HPLC or UHPLC, respectively) coupled to fluorescence detection (FLR), often with inline mass spectrometry (MS). Typically, dextran ladder mobility (GU values) and mass data (m/z) …
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The Challenge of Disruptive Technologies in Bioprocessing
“Various operational challenges and process analytical technologies for inline/ at-line/on-line controls still need to be worked out to achieve success in continuous bioprocessing. This is a highly re…
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Speed and Flexibility Are Dual Goals for Biopharma Operations
Other product introductions included new chromatography columns, inline process monitoring sensors, lab and pilot-scale filtration systems, and pumps and fluid handling systems. Suppliers also introdu…
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Ensuring the Biological Integrity of Raw Materials
According to Sasges, combining inline UV disinfection with other barrier methods for preventing contamination, like filtration, gives you a “belt and suspenders” approach that would be more effective …
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Improving Process-Scale Chromatography
Advances in technology are increasing the productivity and efficiency of commercial-scale chromatography bioprocesses.
By Cynthia Challener, PhD
Chromatography is a crucial step in the purif…
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Process Chromatography Selection for Downstream Processing Applications
Increases in mass demands also mean that storage and buffer tanks can create bottlenecks, thus inline conditioning systems, preparing buffers in-line from stock solutions, become attractive. For the s…
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Continuous Processing for the Production of Biopharmaceuticals
It also offers an easy integration with other unit operations and flexibility of inline addition of additives. Moreover, the proposed unit can seamlessly be placed in a continuous bioprocessing train,…
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Advanced Technologies Facilitate Scale-up and Technology Transfer
“Many of the recent investments at Pall have been driven by this expectation, and our new single-pass tangential flow filtration modules and systems and inline concentrator are examples of technologie…
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Analyzing Proteins Using SEC, MALS, and UHPLC
“A third-party inline fluorescence detector may be combined with Wyatt’s MALS and RI instruments and software to determine unequivocally the molar masses of such complexes. This ability to combine dif…
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Q&As with Industry Leaders
Gregory Lane, Bristol Myers Squibb
Implementation of inline conditioning to advance process intensification
Filippo Bertoli, Senior Associate Scientist, Janssen
Séamus McHugh, Oper…