Search results for " MabSelect"
Article
Optimizing KiH bispecific antibody chromatography steps
… Cytiva developed an optimized capture step for two closely related knob-into-hole (KiH) bsAbs using MabSelect PrismA™ protein A resin which reached a purity of 94%. In addition, two flow-through pol…
Article
Purification strategies for antibody-derived entities: bispecifics and fragments
The diversity of antibody variants in today’s pipeline presents unique challenges for purification. Purification platforms used for many monoclonal antibodies (mAbs) need to be adopted for ant…
Article
Top challenges in recombinant protein purification process development
…ent from mAbs, which do have a great affinity solution that can be used in protein A, such as Cytiva MabSelect PrismA. But then there's also a good platform approach that can be used. So after your a…
Article
Optimization of a two-step purification method for bispecific antibodies
Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can bind two antigens, offering unique modes of action compared to monoclonal antibodies. New and i…
Article
Capture of Bispecific Antibodies and Removal of Product-Related Impurities
In this article, Cytiva presents data on applications using MabSelect™ VL protein L resin with novel selectivity to purify challenging entities.
READ FULL ARTICLE >>
Article
Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator Bioscience AB develops antibody-based pharmaceuticals for cancer treatment, specializing in mono- and bispecific antibodies for tumor-directed immunotherapies. Alligator and Cytiva devel…
Article
Cytiva Advances Fiber Chromatography Technology with New Launch
Using Ology Bio’s mAb platform, we have gained two orders of magnitude greater productivity using Fibro PrismA than MabSelect PrismA resin,” said Ryan Davis, senior scientist at Ology Biosciences, in …
Article
Developing a Closed, Connected Single-Use mAb Purification Process
In the Protein A step, Fibro PrismA is compared with MabSelect PrismA regarding process time, recovery, and purification performance.
Article
Cytiva Invests $500 Million Over 5 Years to Expand Global Capacity
The manufacturing capacity of Cytiva's MabSelect and Capto chromatography product platforms has also doubled as part of a $70-million-per-year (2017–2022) investment in capacity gains and a facility m…
Article
Platform for Purification of VHH-type Antibody Fragments
Click here to read this poster >>
Protein A affinity chromatography resins have been used to purify monoclonal antibodies (mAbs) by the bioprocess industry at all scales for a long time. Howev…