Search results for " modeling" in Articles / App Notes
Article
Sterilization Trends for Single-Use Consumables
“Evolving technologies in digital modeling and dose-delivery mapping during the irradiation process are expected to help optimize the process. In silico techniques can model how boxes of SU systems ar…
Article
Top Process Development Trends for 2021 and a Look into 2022
Implementing Titers, Compliance, Mechanistic Modeling of Chromatography for Smarter Process Development
Bioprocessing has evolved over the past 30 years, and readers how curious how to navigate the…
Article
Improving Upstream Predictability
…pstream processing, from bioreactor design and media development to process control, automation, and modeling.
Some of the most significant gains have been made in cell line expression, adv…
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Advances in Engineering of Protein-Based APIs
Advanced modeling tools are enabling the rapid engineering of more complex proteins with desirable properties. Companies are also paying attention to the developability and manufacturability of protei…
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Scaling Up Novel Therapies
Use of digital modeling is helping developers understand processes at small scale and assess operations before scaling up, he says.
Bioreactors also present opportunities for scaling out…
Article
DoE Provides Benefits, but Preparation Is Necessary
Nov 1, 2014
By: Cynthia Challener, PhD
BioPharm International
Volume 11, Issue 27, pp. 28-29
Using a design-of-experiment (DoE) approach allows a formulation development scientist t…
Article
Continued Process Verification for Biopharma Manufacturing
The authors discuss complications of implementing continued process verification and provide recommended approaches.
Oct 1, 2014
By: Jeff Fleming, Robin Payne
BioPharm International
…
Article
Single-Domain Antibodies for Brain Targeting
Single-domain antibodies are emerging as credible alternatives due to their target specificity, high affinity, and cost-effective recombinant production.
Smaller recombinant antibody fragments a…
Article
Regulatory Challenges in the QbD Paradigm
The authors demonstrate how an integrated model is helping to achieve regulatory flexibility. This article is part of a special section on biopharmaceutical trends.
With the dawn of the 2…
Article
QbD and PAT in Upstream and Downstream Processing
To gain perspective on the implementation of quality by design (QbD) and process analytical technology (PAT) in biopharmaceutical processing, BioPharm International spoke with Clinton Weber, as…