Search results for "virus"
Poster
Development of a chemically defined medium for virus vaccine production in a duck suspension cell line
The primary goal of this project was to develop a chemically defined medium that could be used in a monophasic process while supporting the growth and production of a broad spectrum of different virus…
Article
Concentration and Diafiltration of Cell-Derived, Live Influenza Virus Using 750 C Hollow Fiber Filter Cartridge
Cross flow filtration (CFF) is a technique extensively used in vaccine production and particularly in influenza vaccine manufacturing. In contrast to normal flow (dead-end) filtration (NFF), the fee…
Article
Production of Recombinant Adeno-associated Virus Vectors Using Microcarrier Culture of HEK293T Cells
As the gene therapy projects enter clinical Phase III or get market approval, large-scale production of viruses has become a limiting factor in the industrialization of gene therapy.
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Poster
Reduce Risk of Failure in Your Virus Clearance Study by Choosing Robust Scale-Down Chromatography Tools
Effective viral clearance studies remain one of the challenges facing manufacturers of biologics. These studies are an essential part of process validation and are critical to ensure drug safety. Vi…
Article
Viral Clearance Challenges in Bioprocessing
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Removal and inactivation of adventitious and endogenous viruses have traditionally been achieved during the downstream purification of biologics. Viral clearance is assessed in small-scale te…
Article
Ensuring Viral Safety of Viral Vaccines and Vectors
Viral vaccines rely on antigenic properties of a virus or virus-like particle (VLP) to trigger an immune response against an incipient viral infection. Because of the risks associated with live and in…
Article
Putting Viral Clearance Capabilities to the Test
The studies must be designed to evaluate potential viruses, be representative of the production process, meet regulatory requirements, and provide reportable data. In addition, the testing should be c…
Article
An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
…dies, is associated with the concomitant risk of process/product contamination with endogenous retroviruses, latent viruses, or new and emerging adventitious agents. Cell-culture applications are imp…
Article
Novel Vaccine Technologies Meet the Need for Pandemic and Therapeutic Solutions
Following the 2009 outbreak of the H1N1 pandemic flu and the numerous delays in producing vaccines against the virus, the US Department of Health and Human Services (HHS) recognized the need to invest…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
Viral vaccines specifically can be classified into ‘classic or traditional vaccines’ and include attenuated/killed virus. Recombinant vaccines include subunit, virus-like particle (VLP), conjugate, an…