Search results for " binding"
Article
Implications of Cell Culture Conditions on Protein Glycosylation
Glycosylation can potentially affect a protein’s half-life, immunogenicity, binding activity, and stability. It is a complex process that consists of the attachment of carbohydrate moieties, with poss…
Article
Selecting the Right Viral Clearance Technology
By Cynthia Challener, PhD
The introduction of adventitious viral agents is a recognized, inherent risk of biologic drug production that is well addressed by international regulatory requirements…
Article
Selecting a Comprehensive Bioburden Reduction Plan
Considerations such as membrane porosity, charge, or protein binding may also influence the selection process.
Hutchinson: Undoubtedly, understanding the organisms endemic within the facility play…
Article
Aseptic Processing: Keeping it Safe
Validation of a sterile filter to see how it affects a processing stream can include various elements, including integrity testing, “fit-for-use” requirements, sterilization, stability, binding, compa…
Article
Challenges of Protein Aggregation During Purification
Careful selection of downstream processing conditions is a must.
Sep 1, 2014
By: Cynthia Challener, PhD
BioPharm International
Volume 27, Issue 9, pp. 32-35
Removal of protein a…
Article
Novel Vaccine Technologies Meet the Need for Pandemic and Therapeutic Solutions
New approaches to vaccine production are targeting rapid supply for pandemic situations and broadly effective therapeutic treatments.
Following the 2009 outbreak of the H1N1 pandem…
Article
Monoclonal Antibodies Key to Unlocking the Biosimilars Market
“Antibodies are revolutionary drugs that address previously unmet medical needs by binding to specific targets. However, countless patients around the world do not have access to these state-of-the-ar…
Article
Report from the Eighth International Plasma Product Biotechnology Meeting Melia Salinas, Lanzarote, Spain
Report from the Lanzarote meeting May 13th – 17th, 2013
Yet another well-attended and successful Plasma Product Biotechnology (PPB) meeting has been held. The meeting focu…
Article
Milestones and Moderate Progress in 2012 Drug Approvals
First gene therapy and plant-based expression vector products approved in 2012.
In terms of product approvals, the past year can be considered reasonably successful. Twelve biopharm…