Search results for " binding"
Article
Patenting Prospects for Cell-Based Therapies
…the intracellular domain of human CD3 ζ chain, (b) a costimulatory signaling region, and (c) a binding element that specifically interacts with a selected target, wherein the costimulatory signaling …
Poster
A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
The binding capacity has been increased more than 40% compared to its predecessor MabSelect SuRe LX enabling increased mass throughput and productivity.
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Article
Unifying Continuous Biomanufacturing Operations
In the study, it was determined that countercurrent downstream technologies were key to keeping up with bottlenecks: “The cyclic process was able to load a single column beyond its dynamic binding cap…
Article
Critical Quality Attributes Challenge Biologics Development
The complex nature of biologics adds additional CQAs that must be determined to ensure the safe development of biologics.
By Susan Haigney
Critical quality attributes (CQAs) are used in biop…
Article
Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Enormous success achieved with mAbs can be attributed to their distinctive beneficial properties and advantages, which include high binding specificity and affinity, availability of humanized forms th…
Article
A Platform Approach to Purification of Antibody Fragments
Antibody fragments constitute a promising class of biopharmaceutical products. As compared with full length antibodies, their fragments have unique properties that make them favorable for certain th…
Article
Generating a Fully Processed Antibody
The authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality.
B…
Poster
Residual DNA analysis in influenza vaccine processing
In cell-based influenza vaccine production, the European Pharmacopoeia demands a host cell residual DNA concentration of less than 10 ng per dose. To reliably measure residual DNA in both process sa…
Article
Design and Qualification of Single-Use Systems
The author provides a review of the concepts of design and qualification that apply to single-use systems.
By Jerold M. Martin
Single-use technologies (SUT) have made significant inroads in …
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process.
By Marcos Simon, Juan J. Giner-Casares
Cell…