Search results for " binding" in Articles / App Notes
Article
Biacore Concentration and Ligand-Binding Analyses
Compared to traditional small-molecule drugs, their structures are complex and they can assert their effects by binding with high specificity to more than one target molecule. During development and i…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The multimodal function of the chromatography medium, utilizing both size exclusion and affinity binding, reduces the number of purification steps needed by combining two procedures in one. The proper…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
However, because of their large size, their binding capacity is usually very low and chromatographic media with normal pore sizes used for proteins offer no advantages since the pores are not availabl…
Article
Quality by design for biotechnology products—part 1
Technologies based on combinatorial libraries and transgenic mice can generate a diverse panel of antibodies and protein-based candidates selected for binding and specificity for a target. Further sel…
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Optimizing KiH bispecific antibody chromatography steps
In addition, two flow-through polishing steps using orthogonal binding principles, hydrophobic interaction and hydrophobic/anion exchange, further reduced the impurities to achieve a monomeric purity …
Article
Evaluating the Use of Continuous Chromatography
…nd increased production capacity, for example, through increased utilization of chromatography resin binding capacity, reduced buffer usage, and smaller column size.
BioPharm: What have been the …
Article
FAQs about Cytiva™ Protein Select™ technology
The protocol does not require the use of a protease, and the same buffer can be used for equilibration, binding, wash, and elution.
This FAQ page provides answers to a range of questions covering …
Article
Webinar about a new affinity chromatography technology for recombinant proteins
The protocol does not require the use of a protease, and the same buffer can be used for equilibration, binding, wash, and elution.
Watch this webinar to learn more about this new affinity chrom…
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Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
So you use differential equations to describe mass transfer and adsorption isotherms to describe the binding event. Out of the computer comes simulated chromatograms—1,000 chromatograms in a few minut…
Article
Can Vaccine Development Be Safely Accelerated?
Can Vaccine Development Be Safely Accelerated?
Biopharma companies responding to the COVID-19 outbreak think accelerating the development of vaccines is safe.
By Cynthia A. Ch…