Search results for " binding" in Articles / App Notes
Article
Platform for Purification of VHH-type Antibody Fragments
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Protein A affinity chromatography resins have been used to purify monoclonal antibodies (mAbs) by the bioprocess industry at all scales for a long time. Howev…
Article
Gene Therapies Push Viral Vector Production
Gene Therapies Push Viral Vector Production
Viral vectors show promise as a delivery mechanism for gene therapy, but which virus types are commercially viable?
By Feliza Miraso…
Article
Rapid Cycling Protein A-Based Fiber Chromatography to Address Emerging Downstream Bottlenecks
This structure allows high monoclonal antibody (mAb) binding capacities at very short residence times, which reduces cycle times to minutes instead of the hours needed for resin-based chromatography. …
Article
Capto™ High Productivity Resins
Capto™ chromatography resins give you increased productivity compared with Sepharose™ resins, through high binding capacity and high flow rates.
Explore Capto™ resins now >>
Article
Purification of Plasmid DNA
By switching to modern chromatography resins, Cobra Biologics was able to increase binding capacity and flow rates up to 50% to address the increasing demands for high quality plasmid DNA.
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Article
Biosimilar Quality Requirements
Factors to consider include the expression system, the manufacturing process, physicochemical properties, functional activities, target binding, impurities, the reference product and reference standar…
Article
Best Practices for Selecting a Top-Quality Cell Line
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Leveraging automation and a step-by-step approach are keys to success.
By Cynthia A. Challener
Cell lines determine the performanc…
Article
Overcome Chromatography Challenges with Fiber Adsorbents
This structure allows high mAb binding capacities at very short residence times. As a result, cycle times take minutes compared to the hours needed for resin-based chromatography.
In this article,…
Article
Driving Improved Access to Biosimilars
Driving Improved Access to Biosimilars
New guidance from FDA, including standards for interchangeability, is expected to speed development of biosimilars, but experts warn against oversimplifying ri…
Article
Moving PAT from Concept to Reality
…uminescent proximity homogeneous assay, and fluorescence resonance energy transfer for target and Fc binding analysis; liquid chromatography coupled with ultraviolet, fluorescence, or MS detectors fo…