Search results for " binding" in Articles / App Notes

Article Western Blot Detection: Is Film or a Digital CCD Imager Better?
It is based on building an antibody:protein complex via specific binding of antibodies to proteins immobilized on a membrane and detecting the bound antibody with one of several detection methods. …

Article An Analytical Approach to Biosimilar Drug Development
… glycan profiles; the potency or biological activities; and other functional tests, such as receptor binding. Analytical similarity by itself is not designed to ‘ensure’ biosimilarity, but is…

Article Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
…ure Conditions for a mAb‑Producing CHO Cell Line  •  How to Determine Dynamic Binding Capacity (DBC) of Chromatography Resins

Article Scaling Up Novel Therapies
One example Ransohoff cites is plate-based chromatography resin screening, enabled by technologies such as Cytiva Predictor plates, that allow users to consider binding properties of resins and soluti…

Article Capacity and Performance of a Next Generation Protein A Chromatography Resin
This application note demonstrates the binding capacity and purification performance of MabSelect PrismA in comparison with its predecessor products for both polyclonal and monoclonal antibodies. An i…

Article Making the Move to Continuous Chromatography
Making the Move to Continuous Chromatography Early adopters are benefiting from lower costs and increased productivity. By Cynthia A. Challener Tashatuvango/Shu…

Article Patenting Prospects for Cell-Based Therapies
…the intracellular domain of human CD3 ζ chain, (b) a costimulatory signaling region, and (c) a binding element that specifically interacts with a selected target, wherein the costimulatory signaling …

Article Unifying Continuous Biomanufacturing Operations
In the study, it was determined that countercurrent downstream technologies were key to keeping up with bottlenecks: “The cyclic process was able to load a single column beyond its dynamic binding cap…

Article Critical Quality Attributes Challenge Biologics Development
The complex nature of biologics adds additional CQAs that must be determined to ensure the safe development of biologics. By Susan Haigney Critical quality attributes (CQAs) are used in biop…

Article Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Enormous success achieved with mAbs can be attributed to their distinctive beneficial properties and advantages, which include high binding specificity and affinity, availability of humanized forms th…

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