Search results for " purity" in Articles / App Notes
Article
Virus-like Particles as Therapeutic Moieties of the Future
Sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS–PAGE) can be used to analyze the molecular weight and protein purity of VLPs. The identity of individual capsid proteins can be confirme…
Article
Technology Innovations Improve Process Chromatography Performance
Specific affinity resins are also being developed that enable an effective and straightforward capture step that results in high purity. We can see this trend in new biological targets (e.g., adeno-as…
Article
Design Considerations for a Commercial Cell and Gene Therapy Facility
For biologics and viral vectors, the cells are a byproduct of production and, thus, often get lysed and discarded in the downstream process, which is designed to optimize both the yield and the purity…
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Case Study: Oncolytic Adenovirus Production
Oncolytic viruses constitute a promising therapeutic approach for treatment of cancer. These viruses selectively replicate in tumor cells and effectively kill these cells without harming normal cell…
Article
Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
In order to provide the purity component found in methods such as CE and cationic exchange chromatography, MAM incorporated a new peak detection feature, Rogers explained, so that differential analysi…
Article
Science Focus Fuels Successful Process Development for Startups
On the other hand, she notes that the small group was nimble, very focused, had great tenacity, learned quickly, and was able to make great strides in improving the yield, purity, efficacy, and cycle …
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An Analytical Approach to Biosimilar Drug Development
Specifically, these tests are designed to cover the primary, secondary, and higher order of protein structures; the purity and impurities; the post-translational modification, such as glycan profiles;…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
…on't Get Tied Down by Bed Height
• Combine Chromatography Techniques: Get the Right Purity/Yield of Protein
• Impurity Testing of Biologic Drug Products
• Tools and Solutions for S…
Article
A Look at the Affinity Chromatography Landscape
…trains of Influenza virus than commercially available resins, while offering comparable recovery and purity,” Thom asserts. In a pandemic situation, he notes that production of 40 million doses of fl…
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
In recent testing of current commercial exoglycosidase preparations (17), it was shown that these enzymes are of poor physical purity (see Figure 4A) and many were contaminated with unwanted glycosida…