Search results for " purity" in Articles / App Notes
Article
Purification strategies for antibody-derived entities: bispecifics and fragments
Purification platforms used for many monoclonal antibodies (mAbs) need to be adopted for antibody variants to simplify protocols and improve purity and yield. The safety and efficiency requirement of …
Article
Top Tips for Successful Development of Antibody Chromatography Processes
But working with protein L, that only binds kappa subclass one, three and four, for instance, MabSelect™ VL, you could get a really high purity sample during the capture step. Since the lambda heterod…
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Discovering the unknown: How does in silico process development change PD scientists’ work?
This resulted in improvements in purity and yield of a mixed mode chromatography purification step, and doubled productivity. Mechanistic modeling can also support early-phase development. The technol…
Article
As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
Depending on the structure of the target antibody and the impurity profile, other affinities, like protein L or variants of protein A, may improve purity and increase removal of impurities.
Cytiva…
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Chromatography for the Diversified Antibody Pipeline
I believe we have an intense program on trying to address all the different aspects to receive good purity of the future drugs. The full process of an interaction depends on the amount of water consum…
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Report from the 12th Plasma Product Biotechnology Forum
One of the conclusions from the study was that with just six calibration runs, the model could predict the evolution of yield and purity for different starting materials. The general trend was conside…
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A better way to purify small drug volumes
But purifying viral vectors with methods optimized for other products can affect yield, purity, and cross-contamination.
How does the ÄKTA ready™ 450 system tackle those problems?
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Article
Cell-free Expression Systems Pose Cell Culture Alternative
New technologies for rapid, in-line assessments of product concentration, potency, and purity are also needed. Meanwhile, new analytical, quality assurance, and regulatory approaches are needed to imp…
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Setting Up Bioprocessing Systems for Digital Transformation
Harvey Branton, technology lead, Biologics, CPI, uses the following as a “for example” scenario: step elutions tend to be used from chromatography columns so that the product purity is based on a fixe…
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The Importance of Process Intensification and PAT for Achieving Real-Time Release
Electrophoretic technologies, which are the gold standard for purity, charge heterogeneity, and other analyses, present more challenges due to the need for sample preparation. Mass spectrometry is of …