Search results for " ReadyToProcess"
Article
Efficient concentration of a low-titer bovine IgG with high recovery in low volume
Filtration was performed using ReadyToProcess™ hollow fiber filter cartridges. The described process enabled concentration of a bovine IgG antibody from 50.0 to 0.165 L in less than 5 h.
Poster
Validation of the Production of Influenza Virus
Compared with WAVE Bioreactor 20/50, the successor ReadyToProcess WAVE 25 system allows using a smoother rocking motion to reduce shear. As shear stress is a critical parameter in virus production fro…
Poster
Validation of Cytodex™ Gamma microcarrier-based virus production in single-use bioreactor systems
Here, we describe different approaches for the cultivation of Vero cells using Cytodex and Cytodex Gamma microcarriers in serum-free cultivation medium using spinners, WAVE Bioreactor™ 20/50, ReadyToP…
Article
Perfusion N-1 – A Way to Improve the Fed-Batch Production Process
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In this article, we show how the conventional N-1 seed train step was replaced by a high-density perfusion and how the production bioreactor can be seeded at a 10-fol…
Article
Scalable ADCF Virus Production Using HyClone™ VaccineXpress Medium
The results were used for scaling up the process to a ReadyToProcess WAVE 25 bioreactor system at a 2-L working volume. The data show that the ADCF process using VaccineXpress for rotavirus propagatio…
Article
Achieving Efficient Adenovirus Upstream Production
Adenovirus is one of the most frequently used viral vectors in the development of therapeutic vaccines and vaccines against infectious diseases. Adenovirus has also been explored as a viral vector f…
Article
Single-Use Chromatography: Adapting to Manufacturing Scale
Single-use technologies offer the flexibility needed to meet the demands of multiproduct facilities. The capital investment is lower, and substantial time savings can be made when eliminating cleani…
Article
Taking Prepacked Columns to Manufacturing Scale
Prepacked chromatography columns in biomanufacturing can save time, but also present concerns related to delivery lead times, capacity, and operational cost.
Learn more here about ways to address…
Article
Evaluation of Performance of a Disposable mAb Affinity Chromatography Column Used Over Multiple Process Cycles
This application note demonstrates cycling of ReadyToProcess™ MabSelect SuRe™ LX columns in multiple process runs. Analysis of mAb purity and recovery as well as column bed integrity testing show that…
Article
Extractables Studies for Single Use Systems Used in ADC Manufacturing, Part 1
The low levels of extractables found in this study support the use of ReadyToProcess™ columns and ÄKTA™ ready Flow Kits in ADC processes.
Download the application note.
See Part 2 of th…