Search results for " system" in Articles / App Notes
Article
Downstream Processing for Cell-Based Therapies
The increased demand for hospital and social care, coupled with complex medical interventions, has led to spiralling costs for healthcare systems globally. Advanced therapies, including cell- and gene…
Article
Biopharma Advances Demand Specialized Expertise
Recent investments include the updated/new technologies, new assay strategies, and updated electronic systems and processes.
Lively (PPD): Evolving characterization expectations for biologics have…
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Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Kinetic rate analysis is used to investigate the behavior of the system. Interaction kinetics describes the interaction between one or more components. After the interaction, the components leave each…
Article
Reliability Rooms and the Move to Proactive Supply Chain Management
Inspiration for this program came from the Toyota Production System principle,
\obeya. Grounded in pure, fundamental data analytics, this concept is roughly translated as “gathering all the info…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
For complex unit operations such as process chromatography, mechanistic modeling can assist in developing a systematic approach for process development, monitoring, and control. Models can also be jud…
Article
Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
The systematic small-scale model employed in the current study was predictive of manufacturing-scale freeze-thaw conditions.
Therapeutic proteins, peptides, and antibodies have emerged as highly e…
Article
Perfusion in the 21st Century
Batch processing, in which all raw materials are introduced into the bioreactor at the beginning of the cell-culture process, have largely been replaced with fed-batch systems, in which additional nut…
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Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
Radiation degradation, UV degradation, and thermo-oxidative degradation are all similar chain reactions, and thus, a single polymer stabilization system can be used to prevent initiation of degradatio…
Article
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
…o go to an analyst, whether it's a small molecule or a protein or a biologic, takes time to run on a system. It takes a dedicated person to run that sample. The PAT instrumentation is built into the …
Article
Flexible Facilities for Viral Vector Manufacturing
New flexible facilities
“Flexibility enables manufacturers to leverage different technologies and systems in our plants, which can be beneficial when working with different manufacturing platforms…